Extension of Genetic Marker List Using Unnatural Amino Acid System: An Efficient Genomic Modification Strategy in Escherichia coli.

Extension of Genetic Marker List Using Unnatural Amino Acid System: An Efficient Genomic Modification Strategy in Escherichia coli.
Genetic manipulations together with chromosome engineering are important strategies used to restructure cell metabolism. Lambda/Red (λ/Red)-mediated recombination is probably the most generally utilized strategy for chromosomal modulation in Escherichia coli. However, the effectivity of this technique is considerably hampered by the laborious elimination of the selectable markers.
To overcome the issue, the combination helper plasmid was constructed, pSBC1a-CtR, which comprises Red recombinase, Cre recombinase, and exogenous orthogonal aminoacyl-transfer RNA (tRNA) synthetase/tRNA pairs, permits an unnatural amino acid (UAA) to be genetically encoded on the outlined website of the antibiotic resistance gene-encoded protein. When UAAs are usually not in the tradition medium, there was no expression in the antibiotic resistance gene-encoded protein. Accordingly, the following process of antibiotic gene excising is just not wanted.
To confirm this technique, poxB gene was knocked out efficiently. Furthermore, sequential deletion of three goal genes (galR, ptsG, and pgi) was in a position to generate neurosporene-producing pressure marked by excessive development fee. Thus, the site-specific incorporation UAA mutagenesis system have been used to regulate and broaden the use of conditional selectable marker, and the approach is used to facilitate a speedy steady genome modifying in Escherichia coli.

Genomic Indexing by Somatic Gene Recombination of mRNA/ncRNA – Does It Play a Role in Genomic Mosaicism, Memory Formation, and Alzheimer’s Disease?

Genomic Indexing by Somatic Gene Recombination of mRNA/ncRNA - Does It Play a Role in Genomic Mosaicism, Memory Formation, and Alzheimer's Disease?

Recent proof signifies that genomic individuality of neurons, characterised by DNA-content material variation, is a widespread if not common phenomenon in the human mind that happens naturally however may also present aberrancies which have been linked to the pathomechanism of Alzheimer’s illness and associated neurodegenerative issues.

Etiologically, this genomic mosaic has been prompt to come up from defects of cell cycle regulation that will happen both throughout mind growth or in the mature mind after terminal differentiation of neurons. Here, we purpose to attract consideration in the direction of one other mechanism that can provide rise to genomic individuality of neurons, with far-reaching penalties.

This mechanism has its origin in the transcriptome moderately than in replication defects of the genome, i.e., somatic gene recombination of RNA. We proceed to develop the idea that somatic gene recombination of RNA supplies a physiological course of that, by integration of intronless mRNA/ncRNA into the genome, permits a specific practical state on the degree of the person neuron to be listed.

By insertion of outlined RNAs in a somatic recombination course of, the presence of particular mRNA transcripts inside a particular temporal context could be “frozen” and can function an index that may be recalled at any later level in time. This permits data associated to a particular neuronal state of differentiation and/or exercise related to a reminiscence hint to be fastened. We recommend that this course of is used all through the lifetime of every neuron and might need each advantageous and deleterious penalties.

Genomic Indexing by Somatic Gene Recombination of mRNA/ncRNA - Does It Play a Role in Genomic Mosaicism, Memory Formation, and Alzheimer's Disease?
Genomic Indexing by Somatic Gene Recombination of mRNA/ncRNA – Does It Play a Role in Genomic Mosaicism, Memory Formation, and Alzheimer’s Disease?

Culturomics-based genomics sheds mild on the ecology of the brand new haloarchaeal genus Halosegnis.

The growth of tradition-unbiased strategies has revolutioned our understanding of microbial ecology, particularly by the illustration of the huge hole between the environmentally considerable microbial variety and that accessible by cultivation.

However, tradition-primarily based approaches usually are not solely essential for understanding the evolutionary, metabolic and ecological milieu of microbial variety, but additionally for the event of novel biotechnological functions.

Mouse Monoclonal Anti-PD-1 Antibody [7H6]

TA355052 100 µg Ask for price

Mouse Monoclonal Anti-PD-1 Antibody [4C7]

TA355054 100 µg Ask for price

Mouse Monoclonal Anti-PD-1 Antibody [10B3]

TA355055 100 µg Ask for price

Mouse Anti-Human CD279 (PD-1) mAbConjugated Antibody

CCM019 100ul
EUR 476.4

Mouse Monoclonal Anti-PD-1 Antibody [8A4] (HRP)

TA355051 100 µg Ask for price

Mouse Monoclonal Anti-PD-1 Antibody [7H6] (HRP)

TA355053 100 µg Ask for price

Mouse monoclona Anti-PD-L1 Antibody

TA355105 100 µg Ask for price

Recombinant Monoclonal Anti-PD-1 Antibody, Mouse (2F3)

HGS-S238 100ul
EUR 107
Description: Recombinant Monoclonal Anti-PD-1 Antibody, Mouse (2F3) is expressed from Mouse

Mouse PD-1 Monoclonal Antibody

TA319693 100 µg Ask for price

Mouse Anti-PD-1 IgG Monoclonal Antibody, Clone 2H2H11

7123 1 mg/ml x 0.1 ml
EUR 238
Description: Mouse Anti-PD-1 IgG Monoclonal Antibody

Mouse Anti-Human PD-1 monoclonal antibody, clone JID112

CABT-L2940-100uL500uL 100 uL, 500 uL
EUR 602.4

Anti-PD-1 Antibody

A1384-100 each
EUR 405.6

Anti-PD-1 Antibody

A1384-30T each
EUR 175.2

Anti-PD-1 antibody

STJ190081 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to PD-1 (AS1A13)

Anti-PD-1 Antibody

34067 100ul
EUR 191

Mouse Monoclonal Anti-PD-L2 Antibody [7C7]

TA355063 100 µg Ask for price

Mouse Monoclonal Anti-PD-L2 Antibody [7C1]

TA355064 100 µg Ask for price

Mouse Monoclonal Anti-PD-L1 Antibody [4F2]

TA355066 100 µg Ask for price

Mouse Monoclonal Anti-PD-L1 Antibody [2D6]

TA355069 100 µg Ask for price

Mouse Monoclonal Anti-PD-L1 Antibody [1D7]

TA355071 100 µg Ask for price

Mouse Monoclonal Anti-PD-L2 Antibody [4E10]

TA355061 100 µg Ask for price

Mouse Monoclonal Anti-PD-L2 Antibody [8C12]

TA355062 100 µg Ask for price

Mouse Monoclonal Anti-PD-L2 Antibody [10H6]

TA355065 100 µg Ask for price

Mouse Monoclonal Anti-PD-L1 Antibody [8E12]

TA355067 100 µg Ask for price

Mouse Monoclonal Anti-PD-L1 Antibody [6H10]

TA355068 100 µg Ask for price

Mouse Monoclonal Anti-PD-L1 Antibody [1F11]

TA355070 100 µg Ask for price

Mouse PD-1 / CD279 Monoclonal Antibody

TA319692 100 µg Ask for price

Mouse Anti-Human PD-1 (CD279) Monoclonal antibody, clone J116

CABT-L4461-1mg 1 mg
EUR 1076.4

Mouse Anti-Human PD-1 (CD279) Monoclonal antibody, clone J116

CABT-L4461-5mg 5 mg
EUR 2886

Mouse Anti-Human PD-1 (CD279) Monoclonal antibody, clone J110

CABT-L4466-1mg 1 mg
EUR 1076.4

Mouse Anti-Human PD-1 (CD279) Monoclonal antibody, clone J110

CABT-L4466-5mg 5 mg
EUR 2886

Mouse PD-L1 Antibody

32903-05111 150 ug
EUR 215

Mouse Anti-Human CD274 (PD-L1) mAbConjugated Antibody

CCM025 100ul
EUR 476.4

Mouse Anti-Human CD273 (PD-L2) mAbConjugated Antibody

CCM031 100ul
EUR 476.4

PE Anti-Mouse CD279/PD-1 Antibody

DL21641F-20Tests 20Tests
EUR 152
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PE Anti-Mouse CD279/PD-1 Antibody

DL21641F-50Tests 50Tests
EUR 207.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PE Anti-Mouse CD279/PD-1 Antibody

DL21648F-25ug 25μg
EUR 177.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PE Anti-Mouse CD279/PD-1 Antibody

DL21648F-50ug 50μg
EUR 260
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

anti- PD-1/CD279 antibody

FNab06234 100µg
EUR 702
Description: Antibody raised against PD-1/CD279

anti- PD-1/CD279 antibody

FNab06235 100µg
EUR 702
Description: Antibody raised against PD-1/CD279

APC Anti-Mouse CD279/PD-1 Antibody

DL21642F-20Tests 20Tests
EUR 162.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

APC Anti-Mouse CD279/PD-1 Antibody

DL21642F-50Tests 50Tests
EUR 222.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

APC Anti-Mouse CD279/PD-1 Antibody

DL21649F-25ug 25μg
EUR 200
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

APC Anti-Mouse CD279/PD-1 Antibody

DL21649F-50ug 50μg
EUR 305
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

FITC Anti-Mouse CD279/PD-1 Antibody

DL21640F-20Tests 20Tests
EUR 152
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

FITC Anti-Mouse CD279/PD-1 Antibody

DL21640F-50Tests 50Tests
EUR 207.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

FITC Anti-Mouse CD279/PD-1 Antibody

DL21647F-25ug 25μg
EUR 177.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

FITC Anti-Mouse CD279/PD-1 Antibody

DL21647F-50ug 50μg
EUR 260
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Anti-Human PD-1 Antibody

101-M602 100 µg
EUR 399
Description: Programmed Death1 (PD1) is a type I transmembrane protein belonging to the CD28/CTLA4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA4 and PD1). PD1 is expressed on activated T cells, B cells, myeloid cells, and on a subset of thymocytes. In vitro, ligation of PD1 inhibits TCRmediated T cell proliferation and production of IL1, IL4, IL10, and IFNγ. In addition, PD1 ligation also inhibits BCR mediated signaling. PD1 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. Two B7 family proteins, PDL1 (also called B7H1) and PDL2 (also known as B7DC), have been identified as PD1 ligands. Unlike other B7 family proteins, both PDL1 and PDL2 are expressed in a wide variety of normal tissues including heart, placenta, and activated spleens. The wide expression of PDL1 and PDL2 and the inhibitor effects on PD1 ligation indicate that PD1 might be involved in the regulation of peripheral tolerance and may help prevent autoimmune diseases. The human PD1 gene encodes a 288 amino acid (aa) protein with a putative 20 aa signal peptide, a 148 aa extracellular region with one immuno-globulin-like V-type domain, a 24 aa transmembrane domain, and a 95 aa cytoplasmic region. The cytoplasmic tail contains two tyrosine residues that form the immunoreceptor tyrosinebased inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) that are important in mediating PD1 signaling. Mouse and human PD1 share approximately 60% aa sequence identity.

Anti-Human PD-1 Antibody

101-M820 100 µg
EUR 399
Description: Programmed Death1 (PD1) is a type I transmembrane protein belonging to the CD28/CTLA4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA4 and PD1). PD1 is expressed on activated T cells, B cells, myeloid cells, and on a subset of thymocytes. In vitro, ligation of PD1 inhibits TCRmediated T cell proliferation and production of IL1, IL4, IL10, and IFNγ. In addition, PD1 ligation also inhibits BCR mediated signaling. PD1 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. Two B7 family proteins, PDL1 (also called B7H1) and PDL2 (also known as B7DC), have been identified as PD1 ligands. Unlike other B7 family proteins, both PDL1 and PDL2 are expressed in a wide variety of normal tissues including heart, placenta, and activated spleens. The wide expression of PDL1 and PDL2 and the inhibitor effects on PD1 ligation indicate that PD1 might be involved in the regulation of peripheral tolerance and may help prevent autoimmune diseases. The human PD1 gene encodes a 288 amino acid (aa) protein with a putative 20 aa signal peptide, a 148 aa extracellular region with one immuno-globulin-like V-type domain, a 24 aa transmembrane domain, and a 95 aa cytoplasmic region. The cytoplasmic tail contains two tyrosine residues that form the immunoreceptor tyrosinebased inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) that are important in mediating PD1 signaling. Mouse and human PD1 share approximately 60% aa sequence identity.

Anti-PD-1 (S228P) Antibody

71326 100 µg
EUR 490
Description: Humanized recombinant anti-PD-1 (IgG4) antibody with S228P mutation, expressed in HEK293 cells. This antibody has not been tested with other species.

Anti-PD-1/CD279 antibody

PAab06234 100 ug
EUR 494.4

Anti-PD-1 (PDCD1) antibody

STJ180216 0.1 ml
EUR 254.4

AF647 Anti-Mouse CD279/PD-1 Antibody

DL21646F-20Tests 20Tests
EUR 177.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

AF647 Anti-Mouse CD279/PD-1 Antibody

DL21646F-50Tests 50Tests
EUR 237.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

AF647 Anti-Mouse CD279/PD-1 Antibody

DL21653F-25ug 25μg
EUR 230
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

AF647 Anti-Mouse CD279/PD-1 Antibody

DL21653F-50ug 50μg
EUR 357.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Monoclonal Anti-PD-L1 Antibody, Mouse IgG1 (1G1)

HCB-Y128 20ul
EUR 1080.7
Description: Monoclonal Anti-PD-L1 Antibody, Mouse IgG1 (1G1) is expressed from Mouse Hybridoma.

Anti-PDCD1 / PD-1 / CD279 Reference Antibody (UCB anti-PD-1)

E24CHB066 100 μg
EUR 225
Description: Available in various conjugation types.

Biotin Anti-Mouse CD279/PD-1 Antibody

DL21639F-100ug 100μg
EUR 372.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Biotin Anti-Mouse CD279/PD-1 Antibody

DL21639F-25ug 25μg
EUR 212
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Purified Anti-Mouse CD279/PD-1 Antibody

DL21638F-100ug 100μg
EUR 242
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Purified Anti-Mouse CD279/PD-1 Antibody

DL21638F-50ug 50μg
EUR 177.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Anti-PD-1 Agonistic Antibody

101178-1 50 µg
EUR 335
Description: Anti-PD-1 IgG antibody is a purified recombinant antibody which recognizes human PD1 antigen. This antibody has been functionally tested in two co-culture assays.

Anti-PD-1 Agonistic Antibody

101178-2 100 µg
EUR 460
Description: Anti-PD-1 IgG antibody is a purified recombinant antibody which recognizes human PD1 antigen. This antibody has been functionally tested in two co-culture assays.

Anti-PD-1 Biotinylated Antibody

A1996-100 100 µg
EUR 411.6

Anti-PD-1 Biotinylated Antibody

A1996-30 30 µg
EUR 187.2

Anti-PD-1 Neutralizing Antibody

71120 100 µg
EUR 465
Description: Neutralizing recombinant murine/human chimeric antibody recognizing the PD-L1/PD-L2 binding region of human PD-1. This antibody does not cross-react with mouse PD-1, but does cross-react with monkey (M. fascicularis) PD-1. It has not been tested with other species.

Mouse Anti-Mouse PD-L1 IgG2b Monoclonal Antibody, Clone 3H9G2

7134 2 mg/ml x 5.0 ml
EUR 524

Mouse Anti-PD-L1 IgG Monoclonal Antibody, Clone 3A9F12

7122 1 mg/ml x 0.1 ml
EUR 238
Description: Mouse Anti-PD-L1 IgG Monoclonal Antibody

Mouse Anti-Human PD-L1 monoclonal antibody, clone JID522

CABT-L2928-100uL500uL 100 uL, 500 uL
EUR 602.4

PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody

DL21643F-20Tests 20Tests
EUR 177.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody

DL21643F-50Tests 50Tests
EUR 237.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PE/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody

DL21644F-20Tests 20Tests
EUR 177.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PE/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody

DL21644F-50Tests 50Tests
EUR 237.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody

DL21650F-25ug 25μg
EUR 245
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody

DL21650F-50ug 50μg
EUR 365
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PE/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody

DL21651F-25ug 25μg
EUR 230
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PE/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody

DL21651F-50ug 50μg
EUR 357.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PerCP/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody

DL21645F-20Tests 20Tests
EUR 177.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PerCP/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody

DL21645F-50Tests 50Tests
EUR 237.5
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PerCP/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody

DL21652F-25ug 25μg
EUR 260
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

PerCP/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody

DL21652F-50ug 50μg
EUR 395
Description: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

SensiStain™ Anti-PD-1 Antibody

HY000211 0.1 ml
EUR 91

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI3A1

TA807889 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI3A1

TA807889S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI7B4

TA807995 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI7B4

TA807995S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI9G6

TA808034 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI9G6

TA808034S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI1D1

TA808035 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI1D1

TA808035S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI6F5

TA807861 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI6F5

TA807861S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI4E10

TA807880 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI4E10

TA807880S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI13A3

TA807888 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI13A3

TA807888S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI17F7

TA807988 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI17F7

TA807988S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI18F2

TA808002 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI18F2

TA808002S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI27G3

TA808033 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI27G3

TA808033S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI13B5

TA808043 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI13B5

TA808043S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI22A9

TA808069 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI22A9

TA808069S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI21F5

TA806927 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI21F5

TA806927S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI16D4

TA806929 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI16D4

TA806929S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI14C5

TA806940 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI14C5

TA806940S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI14B3

TA806961 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI14B3

TA806961S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI27E8

TA807094 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI27E8

TA807094S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI26C4

TA807098 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI26C4

TA807098S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI17G9

TA807207 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI17G9

TA807207S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI15B5

TA807847 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI15B5

TA807847S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI18E8

TA807862 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI18E8

TA807862S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI26F7

TA807864 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI26F7

TA807864S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI13D4

TA807866 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI13D4

TA807866S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI1B11

TA807867 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI1B11

TA807867S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI12G4

TA807868 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI12G4

TA807868S 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB197

UM800089 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB198

UM800090 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB199

UM800091 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone UMAB222

UM800114 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB197

UM870089 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB198

UM870090 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB199

UM870091 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone UMAB222

UM870114 30 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI28F12

TA807865 100 µl Ask for price

PD-1 (PDCD1) mouse monoclonal antibody, clone OTI28F12

TA807865S 30 µl Ask for price

Anti-PD-1 (Toripalimab), Humanized Antibody

A2161-100 100 µg
EUR 612

Anti-PD-1 (Nivolumab) Biotinylated Antibody

A2117-100 100 µg
EUR 411.6

Anti-PD-1 (Nivolumab) Biotinylated Antibody

A2117-30T 30 µg
EUR 187.2

Anti-PD-1 (Camrelizumab) humanized Antibody

A2132-100 100 µg
EUR 636

Anti-PD-1 (Pembrolizumab), humanized Antibody

A1306-100 each
EUR 601.2

Anti-PD-1 (Spartalizumab) humanized Antibody

A2131-100 100 µg
EUR 636

anti- PD-ECGF antibody

FNab06264 100µg
EUR 702
Description: Antibody raised against PD-ECGF

Anti-PD-L1 Antibody

A1454-100 each
EUR 405.6

Anti-PD-L1 Antibody

A1454-30T each
EUR 175.2

Anti-PD-L1 antibody

STJ130022 50 µl
EUR 385.2
Description: Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.

Anti-PD-L1 antibody

STJ130023 50 µl
EUR 385.2
Description: Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.

Anti-PD-L1 antibody

STJ130024 50 µl
EUR 385.2
Description: Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.

Anti-PD-L2 antibody

STJ98748 200 µl
EUR 236.4
Description: Rabbit polyclonal to PD-L2.

Anti-PD-L1 antibody

STJ180217 0.1 ml
EUR 336

Anti-PD-L1 antibody

STJ180383 0.1 ml
EUR 295.2

Anti-PD-L1 antibody

STJ190082 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to PD-L1 (AS1A7)

Anti-PD-L1 Antibody

34068 100ul
EUR 233

PD-1 Antibody

24505-100ul 100ul
EUR 468

PD-1 Antibody

24506-100ul 100ul
EUR 468

In this research, we used a culturomics-primarily based strategy in order to isolate novel microbial taxa from hypersaline environments (i.e. Isla Cristina and Isla Bacuta salterns in Huelva, Spain). We managed to acquire axenic cultures of 4 haloarchaeal strains that belong to a new haloarchaeal genus, and to acquire their genomic sequences.

The phylogenomic and phylogenetic analyses (along with AAI, ANI and digital DDH indices) confirmed that the isolates represent two new species, for which we suggest the names Halosegnis longus sp. nov. and Halosegnis rubeus sp. nov.

The genomic-primarily based metabolic reconstructions indicated that members of this new haloarchaeal genus have photoheterotrophic cardio way of life with a typical salt-in signature. 16S rRNA gene sequence reads abundance profiles and genomic recruitment analyses revealed that the Halosegnis genus has a worldwide geographical distribution, reaching excessive abundance (as much as 8%) in habitats with intermediate salinities.