Human ADCY2(Adenylate Cyclase 2, Brain) ELISA Kit

Human ADCY2(Adenylate Cyclase 2, Brain) ELISA Kit

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Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

EKU02139-5x96T 5x96T
EUR 3580.55

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

EKU02139-96T 96T
EUR 753.8

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

DL-ADCY2-Hu 96T
EUR 421
Description: tissue homogenates, cell lysates or other biological fluids.

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

EK12449 96Т
EUR 768

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

abx251963-96tests 96 tests
EUR 848.4

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

20-abx150558
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

RDR-ADCY2-Hu-48T 48T
EUR 453.92
Description: tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

RDR-ADCY2-Hu-48Tests 48 Tests
EUR 626.4

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

RDR-ADCY2-Hu-96T 96T
EUR 648.38
Description: tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

RDR-ADCY2-Hu-96Tests 96 Tests
EUR 868.8

Human Adenylate Cyclase 2, Brain(ADCY2)ELISA Kit

QY-E00871 96T
EUR 433.2

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

SEB403Hu-10x96wellstestplate 10x96-wells test plate
EUR 5402.92
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adenylate Cyclase 2, Brain (ADCY2) in Tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

SEB403Hu-1x48wellstestplate 1x48-wells test plate
EUR 550.13
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adenylate Cyclase 2, Brain (ADCY2) in Tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

SEB403Hu-1x96wellstestplate 1x96-wells test plate
EUR 734.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adenylate Cyclase 2, Brain (ADCY2) in Tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

SEB403Hu-5x96wellstestplate 5x96-wells test plate
EUR 2945.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adenylate Cyclase 2, Brain (ADCY2) in Tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

4-SEB403Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Adenylate Cyclase 2, Brain (ADCY2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

RD-ADCY2-Hu-48T 48T
EUR 432.3
Description: tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

RD-ADCY2-Hu-48Tests 48 Tests
EUR 600

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

RD-ADCY2-Hu-96T 96T
EUR 617.5
Description: tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

RD-ADCY2-Hu-96Tests 96 Tests
EUR 830.4

Human Adenylate Cyclase 2, Brain (ADCY2)ELISA Kit

YLA3560HU-48T 48T Ask for price

Human Adenylate Cyclase 2, Brain (ADCY2)ELISA Kit

YLA3560HU-96T 96T Ask for price

ELISA kit for Human ADCY2 (Adenylate Cyclase 2, Brain)

ELK1971 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Adenylate Cyclase 2, Brain from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Pig Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

abx361203-96tests 96 tests
EUR 990

ELISA Kit for Adenylate Cyclase 2, Brain (ADCY2)

SEB403Hu 96Т
EUR 665

ADCY2 (untagged)-Human adenylate cyclase 2 (brain) (ADCY2)

SC128073 10 µg Ask for price

ADCY2 (untagged)-Human adenylate cyclase 2 (brain) (ADCY2)

SC318492 10 µg Ask for price

Human Adenylate Cyclase 2, Brain, ADCY2 GENLISA ELISA

KBH2984 1 x 96 wells
EUR 286

Rabbit Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

abx362931-96tests 96 tests
EUR 990

Monkey Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

abx359407-96tests 96 tests
EUR 990

Chicken Adenylate Cyclase 2, Brain (ADCY2) ELISA Kit

abx356000-96tests 96 tests
EUR 990

Human Adenylate Cyclase 2, Brain (ADCY2) CLIA Kit

20-abx492725
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

ADCY2 (GFP-tagged) - Human adenylate cyclase 2 (brain) (ADCY2)

RG222444 10 µg Ask for price

Human Adenylate Cyclase 2, Brain (ADCY2) Protein

20-abx065152
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Adenylate Cyclase 2, Brain (ADCY2) Antibody

abx038430-100ug 100 ug
EUR 469.2

Adenylate Cyclase 2, Brain (ADCY2) Antibody

20-abx171086
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  • 1 mg
  • 200 ug

Adenylate Cyclase 2, Brain (ADCY2) Antibody

20-abx147695
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  • 100 ug
  • 50 ug

Adenylate Cyclase 2, Brain (ADCY2) Antibody

20-abx135749
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Adenylate Cyclase 2, Brain (ADCY2) Antibody

20-abx102704
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Adenylate Cyclase 2, Brain (ADCY2) Antibody

abx026205-400ul 400 ul
EUR 627.6

Adenylate Cyclase 2, Brain (ADCY2) Antibody

abx026205-80l 80 µl
EUR 343.2

Recombinant Adenylate Cyclase 2, Brain (ADCY2)

RPU40099-100ug 100ug
EUR 542.3

Recombinant Adenylate Cyclase 2, Brain (ADCY2)

RPU40099-1mg 1mg
EUR 2402.4

Recombinant Adenylate Cyclase 2, Brain (ADCY2)

RPU40099-50ug 50ug
EUR 435.6

Recombinant Adenylate Cyclase 2, Brain (ADCY2)

RPB403Hu01 10ug
EUR 176

Recombinant Adenylate Cyclase 2, Brain (ADCY2)

4-RPB403Hu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Adenylate Cyclase 2, Brain expressed in: E.coli

ADCY2 (Myc-DDK-tagged)-Human adenylate cyclase 2 (brain) (ADCY2)

RC222444 10 µg Ask for price

Human ADCY1(Adenylate Cyclase 1, Brain) ELISA Kit

ELK1533-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ADCY1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ADCY1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human ADCY1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ADCY1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human ADCY1(Adenylate Cyclase 1, Brain) ELISA Kit

ELK1533-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ADCY1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ADCY1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human ADCY1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ADCY1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human ADCY1 (Adenylate Cyclase 1, Brain) ELISA Kit

EKE60201-5x96T 5x96T
EUR 3124.08

Human ADCY1 (Adenylate Cyclase 1, Brain) ELISA Kit

EKE60201-96T 96T
EUR 657.7

Adenylate Cyclase 2, Brain (ADCY2) Polyclonal Antibody (Human)

4-PAB403Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Adenylate Cyclase 2, Brain (ADCY2)

Adenylate Cyclase 2, Brain (ADCY2) Polyclonal Antibody

CAU26002-100ul 100ul
EUR 222.7

Adenylate Cyclase 2, Brain (ADCY2) Polyclonal Antibody

CAU26002-200ul 200ul
EUR 278.9

Human Adenylate Cyclase 10, Brain (ADCY10)ELISA Kit

201-12-2461 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Adenylate Cyclase 10( Brain(ADCY10)ELISA Kit

QY-E00872 96T
EUR 433.2

Human Adenylate Cyclase 10, Brain (ADCY10)ELISA Kit

YLA3139HU-48T 48T Ask for price

Human Adenylate Cyclase 10, Brain (ADCY10)ELISA Kit

YLA3139HU-96T 96T Ask for price

Adcy2 (untagged ORF) - Rat adenylate cyclase 2 (brain) (Adcy2), (10 ug)

RN208260 10 µg Ask for price

Human Adenylate Cyclase 4, Brain (ADCY4)ELISA Kit

201-12-1468 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1)ELISA Kit

201-12-2023 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Adenylate Cyclase 8, Brain (ADCY8)ELISA Kit

201-12-2034 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Adenylate Cyclase 6, Brain (ADCY6)ELISA Kit

201-12-2159 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Adenylate Cyclase 7, Brain (ADCY7)ELISA Kit

201-12-2206 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Adenylate Cyclase 3, Brain (ADCY3)ELISA Kit

201-12-2266 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Adenylate Cyclase 5, Brain (ADCY5)ELISA Kit

201-12-2456 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Adenylate Cyclase 9, Brain (ADCY9)ELISA Kit

201-12-3218 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

DLR-ADCY1-Hu 96T
EUR 443
Description: tissue homogenates, cell lysates or other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

DLR-ADCY1-Hu-48T 48T
EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Adenylate Cyclase 1, Brain (ADCY1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

DLR-ADCY1-Hu-96T 96T
EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Adenylate Cyclase 1, Brain (ADCY1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

EKN43247-48T 48T
EUR 359.87

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

EKN43247-5x96T 5x96T
EUR 2441.98

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

EKN43247-96T 96T
EUR 514.1

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

EKU02136-48T 48T
EUR 527.66

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

EKU02136-5x96T 5x96T
EUR 3580.55

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

EKU02136-96T 96T
EUR 753.8

Human Adenylate Cyclase 4( Brain(ADCY4)ELISA Kit

GA-E1484HM-48T 48T
EUR 346.8

Human Adenylate Cyclase 4( Brain(ADCY4)ELISA Kit

GA-E1484HM-96T 96T
EUR 559.2

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

DL-ADCY1-Hu 96T
EUR 421
Description: tissue homogenates, cell lysates or other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

EK12448 96Т
EUR 768

Human Adenylate Cyclase 8, Brain (ADCY8) ELISA Kit

20-abx385629
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

abx250802-96tests 96 tests
EUR 904.8

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

20-abx150557
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

RDR-ADCY1-Hu-48T 48T
EUR 453.92
Description: tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

RDR-ADCY1-Hu-48Tests 48 Tests
EUR 626.4

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

RDR-ADCY1-Hu-96T 96T
EUR 648.38
Description: tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

RDR-ADCY1-Hu-96Tests 96 Tests
EUR 868.8

Human Adenylate Cyclase 9, Brain(ADCY9)ELISA Kit

QY-E00864 96T
EUR 433.2

Human Adenylate Cyclase 8, Brain(ADCY8)ELISA Kit

QY-E00865 96T
EUR 433.2

Human Adenylate Cyclase 7, Brain(ADCY7)ELISA Kit

QY-E00866 96T
EUR 433.2

Human Adenylate Cyclase 6( Brain(ADCY6)ELISA Kit

QY-E00867 96T
EUR 433.2

Human Adenylate Cyclase 5( Brain(ADCY5)ELISA Kit

QY-E00868 96T
EUR 433.2

Human Adenylate Cyclase 4( Brain(ADCY4)ELISA Kit

QY-E00869 96T
EUR 433.2

Human Adenylate Cyclase 3( Brain(ADCY3)ELISA Kit

QY-E00870 96T
EUR 433.2

Human Adenylate Cyclase 1( Brain(ADCY1)ELISA Kit

QY-E00873 96T
EUR 433.2

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

SEB348Hu-10x96wellstestplate 10x96-wells test plate
EUR 5402.92
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adenylate Cyclase 1, Brain (ADCY1) in Tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

SEB348Hu-1x48wellstestplate 1x48-wells test plate
EUR 550.13
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adenylate Cyclase 1, Brain (ADCY1) in Tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

SEB348Hu-1x96wellstestplate 1x96-wells test plate
EUR 734.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adenylate Cyclase 1, Brain (ADCY1) in Tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

SEB348Hu-5x96wellstestplate 5x96-wells test plate
EUR 2945.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adenylate Cyclase 1, Brain (ADCY1) in Tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

4-SEB348Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Adenylate Cyclase 1, Brain (ADCY1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

RD-ADCY1-Hu-48T 48T
EUR 432.3
Description: tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

RD-ADCY1-Hu-48Tests 48 Tests
EUR 600

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

RD-ADCY1-Hu-96T 96T
EUR 617.5
Description: tissue homogenates, cell lysates and other biological fluids.

Human Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit

RD-ADCY1-Hu-96Tests 96 Tests
EUR 830.4

Human Adenylate Cyclase 1, Brain (ADCY1)ELISA Kit

YLA2888HU-48T 48T Ask for price

Human Adenylate Cyclase 1, Brain (ADCY1)ELISA Kit

YLA2888HU-96T 96T Ask for price

Human Adenylate Cyclase 8, Brain (ADCY8)ELISA Kit

YLA2893HU-48T 48T Ask for price

Human Adenylate Cyclase 8, Brain (ADCY8)ELISA Kit

YLA2893HU-96T 96T Ask for price

Human Adenylate Cyclase 6, Brain (ADCY6)ELISA Kit

YLA2943HU-48T 48T Ask for price

Human Adenylate Cyclase 6, Brain (ADCY6)ELISA Kit

YLA2943HU-96T 96T Ask for price

Human Adenylate Cyclase 7, Brain (ADCY7)ELISA Kit

YLA2961HU-48T 48T Ask for price

Human Adenylate Cyclase 7, Brain (ADCY7)ELISA Kit

YLA2961HU-96T 96T Ask for price

Human Adenylate Cyclase 3, Brain (ADCY3)ELISA Kit

YLA3007HU-48T 48T Ask for price

Human Adenylate Cyclase 3, Brain (ADCY3)ELISA Kit

YLA3007HU-96T 96T Ask for price

Human Adenylate Cyclase 5, Brain (ADCY5)ELISA Kit

YLA3136HU-48T 48T Ask for price

Human Adenylate Cyclase 5, Brain (ADCY5)ELISA Kit

YLA3136HU-96T 96T Ask for price

Human Adenylate Cyclase 9, Brain (ADCY9)ELISA Kit

YLA3557HU-48T 48T Ask for price

Human Adenylate Cyclase 9, Brain (ADCY9)ELISA Kit

YLA3557HU-96T 96T Ask for price

Human Adenylate Cyclase 4, Brain (ADCY4)ELISA Kit

YLA2651HU-48T 48T Ask for price

Human Adenylate Cyclase 4, Brain (ADCY4)ELISA Kit

YLA2651HU-96T 96T Ask for price

Adenylate Cyclase 2, Brain (ADCY2) Polyclonal Antibody (Human), PE

4-PAB403Hu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Adenylate Cyclase 2, Brain (ADCY2). This antibody is labeled with PE.

Adenylate Cyclase 2, Brain (ADCY2) Polyclonal Antibody (Human), APC

4-PAB403Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Adenylate Cyclase 2, Brain (ADCY2). This antibody is labeled with APC.

Adenylate Cyclase 2, Brain (ADCY2) Polyclonal Antibody (Human), Cy3

4-PAB403Hu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Adenylate Cyclase 2, Brain (ADCY2). This antibody is labeled with Cy3.

Adenylate Cyclase 2, Brain (ADCY2) Polyclonal Antibody (Human), HRP

4-PAB403Hu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Adenylate Cyclase 2, Brain (ADCY2). This antibody is labeled with HRP.

ELISA kit for Human ADCY1 (Adenylate Cyclase 1, Brain)

E-EL-H0267 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human ADCY1 (Adenylate Cyclase 1, Brain) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human ADCY1 (Adenylate Cyclase 1, Brain)

ELK1533 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Adenylate Cyclase 1, Brain from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human ADCY2(Adenylate Cyclase 2, Brain) ELISA Kit