Machine learning (ML) provides a broad framework for addressing high-dimensional prediction problems in classification and regression. While ML is often applied for imaging problems in medical physics, there are many efforts to apply these principles to biological data toward questions of radiation biology.
Here, we provide a review of radiogenomics modeling frameworks and efforts toward genomically guided radiotherapy. We first discuss medical oncology efforts to develop precision biomarkers. We next discuss similar efforts to create clinical assays for normal tissue or tumor radiosensitivity. We then discuss modeling frameworks for radiosensitivity and the evolution of ML to create predictive models for radiogenomics.
Genomic footprints of an old affair: SNP data reveal historical hybridization and the subsequent evolution of reproductive barriers in two recently diverged grasshoppers with partly overlapping distributions.
Secondary contact in close relatives can result in hybridization and the admixture of previously isolated gene pools. However, after an initial period of hybridization, reproductive isolation can evolve through different processes and lead to the interruption of gene flow and the completion of the speciation process. Omocestus minutissimus and O. uhagonii are two closely related grasshoppers with partially overlapping distributions in the Central System mountains of the Iberian Peninsula.
To analyse spatial patterns of historical and/or contemporary hybridization between these two taxa and understand how species boundaries are maintained in the region of secondary contact, we sampled sympatric and allopatric populations of the two species and obtained genome-wide SNP data using a restriction site-associated DNA sequencing approach. We used Bayesian clustering analyses to test the hypothesis of contemporary hybridization in sympatric populations and employed a suite of phylogenomic approaches and a coalescent-based simulation framework to evaluate alternative hypothetical scenarios of interspecific gene flow.
 RAT ANTI MOUSE IgG1 |
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MBS235035-5x1mg |
MyBiosource |
5x1mg |
EUR 3220 |
 Goat anti Mouse IgG1 |
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20R-IG003 |
Fitzgerald |
1 mg |
EUR 213 |
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Description: Goat anti Mouse IgG1 antibody |
 Goat anti Mouse IgG1 |
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FNSA-0086 |
FN Test |
500 uL |
EUR 367.92 |
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Description: Goat anti Mouse IgG1 secondary antibody |
 GOAT ANTI MOUSE IgG1 |
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MBS235403-05mg |
MyBiosource |
0.5mg |
EUR 265 |
GOAT ANTI MOUSE IgG1 |
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MBS235403-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1020 |
Goat anti Mouse IgG1 |
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MBS316340-1mg |
MyBiosource |
1mg |
EUR 560 |
Goat anti Mouse IgG1 |
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MBS316340-5x1mg |
MyBiosource |
5x1mg |
EUR 2350 |
Goat anti Mouse IgG1 |
|
MBS534827-1mg |
MyBiosource |
1mg |
EUR 400 |
Goat anti Mouse IgG1 |
|
MBS534827-5x1mg |
MyBiosource |
5x1mg |
EUR 1660 |
 Rabbit anti Mouse IgG1 |
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41C-CB5120 |
Fitzgerald |
1 mg |
EUR 302 |
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Description: Rabbit anti Mouse IgG1 secondary antibody |
Rabbit anti Mouse IgG1 |
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MBS539799-1mg |
MyBiosource |
1mg |
EUR 540 |
Rabbit anti Mouse IgG1 |
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MBS539799-5x1mg |
MyBiosource |
5x1mg |
EUR 2280 |
 Mouse anti Rat IgG1 |
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41R-1117 |
Fitzgerald |
100 ug |
EUR 218 |
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Description: Mouse anti Rat IgG1 secondary antibody |
 MOUSE ANTI PIG IgG1 |
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MBS219900-01mg |
MyBiosource |
0.1mg |
EUR 410 |
MOUSE ANTI PIG IgG1 |
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MBS219900-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1670 |
 Mouse anti Human IgG1 |
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10-I21A |
Fitzgerald |
200 ug |
EUR 429 |
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Description: Mouse anti Human IgG1 antibody |
Mouse anti Human IgG1 |
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10R-I110a |
Fitzgerald |
1 ml |
EUR 1990 |
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Description: Mouse anti Human IgG1 antibody |
Mouse anti Human IgG1 |
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10R-I127a |
Fitzgerald |
1 mg |
EUR 429 |
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Description: Mouse anti Human IgG1 antibody |
 MOUSE ANTI HUMAN IgG1 |
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MBS211708-05mg |
MyBiosource |
0.5mg |
EUR 585 |
MOUSE ANTI HUMAN IgG1 |
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MBS211708-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2450 |
Mouse anti Human IgG1 |
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MBS530111-1mg |
MyBiosource |
1mg |
EUR 620 |
Mouse anti Human IgG1 |
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MBS530111-5x1mg |
MyBiosource |
5x1mg |
EUR 2640 |
Mouse anti Human IgG1 |
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MBS531698-1mg |
MyBiosource |
1mg |
EUR 790 |
Mouse anti Human IgG1 |
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MBS531698-5x1mg |
MyBiosource |
5x1mg |
EUR 3405 |
Mouse anti Human IgG1 |
|
MBS530772-05mg |
MyBiosource |
0.5mg |
EUR 1160 |
Mouse anti Human IgG1 |
|
MBS530772-5x05mg |
MyBiosource |
5x0.5mg |
EUR 5065 |
 MOUSE ANTI BOVINE IgG1 |
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MBS219886-01mg |
MyBiosource |
0.1mg |
EUR 370 |
MOUSE ANTI BOVINE IgG1 |
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MBS219886-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1500 |
MOUSE ANTI BOVINE IgG1 |
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MBS219904-01mg |
MyBiosource |
0.1mg |
EUR 410 |
MOUSE ANTI BOVINE IgG1 |
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MBS219904-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1670 |
) Goat anti Mouse IgG1 (HRP) |
|
43R-IG060hrp |
Fitzgerald |
1 mg |
EUR 457.2 |
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Description: Goat anti Mouse IgG1 secondary antibody (HRP) |
 GOAT ANTI MOUSE IgG1:HRP |
|
MBS235406-1mL |
MyBiosource |
1mL |
EUR 320 |
GOAT ANTI MOUSE IgG1:HRP |
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MBS235406-5x1mL |
MyBiosource |
5x1mL |
EUR 1255 |
 GOAT ANTI MOUSE IgG1:RPE |
|
MBS235407-01mg |
MyBiosource |
0.1mg |
EUR 430 |
GOAT ANTI MOUSE IgG1:RPE |
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MBS235407-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1770 |
) Goat anti Mouse IgG1 (FITC) |
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43R-1648 |
Fitzgerald |
1 mg |
EUR 324 |
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Description: Goat anti Mouse IgG1 secondary antibody (FITC) |
 GOAT ANTI MOUSE IgG1:FITC |
|
MBS235405-05mg |
MyBiosource |
0.5mg |
EUR 290 |
GOAT ANTI MOUSE IgG1:FITC |
|
MBS235405-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1135 |
) Rabbit anti Mouse IgG1 (HRP) |
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43R-IR009HRP |
Fitzgerald |
1 mg |
EUR 406.8 |
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Description: Rabbit anti Mouse IgG1 secondary antibody (HRP) |
 RABBIT ANTI MOUSE IgG1:HRP |
|
MBS220453-1mg |
MyBiosource |
1mg |
EUR 685 |
RABBIT ANTI MOUSE IgG1:HRP |
|
MBS220453-5x1mg |
MyBiosource |
5x1mg |
EUR 2910 |
Rabbit anti Mouse IgG1 (HRP) |
|
MBS539149-1mg |
MyBiosource |
1mg |
EUR 710 |
Rabbit anti Mouse IgG1 (HRP) |
|
MBS539149-5x1mg |
MyBiosource |
5x1mg |
EUR 3045 |
) Rabbit anti Mouse IgG1 (FITC) |
|
43C-CB1521 |
Fitzgerald |
1 mg |
EUR 351 |
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Description: Rabbit anti Mouse IgG1 secondary antibody (FITC) |
 GOAT ANTI MOUSE IgG1:Biotin |
|
MBS235083-1mg |
MyBiosource |
1mg |
EUR 685 |
GOAT ANTI MOUSE IgG1:Biotin |
|
MBS235083-5x1mg |
MyBiosource |
5x1mg |
EUR 2905 |
Rabbit anti Mouse IgG1 (FITC) |
|
MBS538727-1mg |
MyBiosource |
1mg |
EUR 610 |
Rabbit anti Mouse IgG1 (FITC) |
|
MBS538727-5x1mg |
MyBiosource |
5x1mg |
EUR 2585 |
) Rabbit anti Mouse IgG1 (biotin) |
|
43C-CB5124 |
Fitzgerald |
1 mg |
EUR 355 |
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Description: Rabbit anti Mouse IgG1 secondary antibody (biotin) |
Rabbit anti Mouse IgG1 (biotin) |
|
43R-IR008bt |
Fitzgerald |
1 mg |
EUR 355 |
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Description: Rabbit anti Mouse IgG1 secondary antibody (biotin) |
Rabbit anti Mouse IgG1 (biotin) |
|
MBS538762-1mg |
MyBiosource |
1mg |
EUR 620 |
Rabbit anti Mouse IgG1 (biotin) |
|
MBS538762-5x1mg |
MyBiosource |
5x1mg |
EUR 2635 |
Rabbit anti Mouse IgG1 (biotin) |
|
MBS539019-1mg |
MyBiosource |
1mg |
EUR 620 |
Rabbit anti Mouse IgG1 (biotin) |
|
MBS539019-5x1mg |
MyBiosource |
5x1mg |
EUR 2635 |
 Anti-CRP [P03], Mouse IgG1 |
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MBS488975-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-CRP [P03], Mouse IgG1 |
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MBS488975-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
 Anti-CRP [P24], Mouse IgG1 |
|
MBS488977-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-CRP [P24], Mouse IgG1 |
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MBS488977-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
 Anti-CCR5 [ST6], Mouse IgG1 |
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MBS488925-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-CCR5 [ST6], Mouse IgG1 |
|
MBS488925-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
) Rabbit anti Mouse IgG1 (rhodamine) |
|
43C-CB5122 |
Fitzgerald |
1 mg |
EUR 355 |
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Description: Rabbit anti Mouse IgG1 secondary antibody (Rhodamine) |
Rabbit anti Mouse IgG1 (rhodamine) |
|
MBS538760-1mg |
MyBiosource |
1mg |
EUR 620 |
Rabbit anti Mouse IgG1 (rhodamine) |
|
MBS538760-5x1mg |
MyBiosource |
5x1mg |
EUR 2635 |
 Anti-Tau [MN423], Mouse IgG1 |
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MBS488957-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-Tau [MN423], Mouse IgG1 |
|
MBS488957-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
 Anti-MUC1 [PAM4], Mouse IgG1 |
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MBS488965-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-MUC1 [PAM4], Mouse IgG1 |
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MBS488965-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
 Anti-CD28 [15E8], Mouse IgG1 |
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MBS488979-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-CD28 [15E8], Mouse IgG1 |
|
MBS488979-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
 Anti-IL2R [AHT54], Mouse IgG1 |
|
MBS488902-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-IL2R [AHT54], Mouse IgG1 |
|
MBS488902-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
 Anti-Normal Mouse IgG1 Antibody |
|
MBS4158475-01mg |
MyBiosource |
0.1mg |
EUR 1055 |
Anti-Normal Mouse IgG1 Antibody |
|
MBS4158475-5x01mg |
MyBiosource |
5x0.1mg |
EUR 4485 |
) Mouse anti Rat IgG1 (HRP) |
|
43R-1582 |
Fitzgerald |
100 ug |
EUR 233 |
|
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Description: Mouse anti Rat IgG1 antibody (HRP) |
 Anti-EGFR [Matuzumab], Mouse IgG1 |
|
MBS488887-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-EGFR [Matuzumab], Mouse IgG1 |
|
MBS488887-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
) Mouse anti Human IgG1 (HRP) |
|
43-1003 |
Fitzgerald |
1 ml |
EUR 263 |
|
|
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Description: Mouse Anti-Human IgG1, Fc-HRP |
) Mouse Anti Human IgG1 (HRP) |
|
MBS5311067-1mL |
MyBiosource |
1mL |
EUR 455 |
Mouse Anti Human IgG1 (HRP) |
|
MBS5311067-5x1mL |
MyBiosource |
5x1mL |
EUR 1905 |
 Mouse anti-Cow IgG1 Antibody |
|
abx401338-01mg |
Abbexa |
0.1 mg |
EUR 543.6 |
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Mouse anti-Cow IgG1 Antibody |
|
abx401394-01mg |
Abbexa |
0.1 mg |
EUR 610.8 |
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 Mouse anti-Pig IgG1 Antibody |
|
abx401399-01mg |
Abbexa |
0.1 mg |
EUR 610.8 |
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 Mouse Anti-Cow IgG1 Antibody |
|
abx401338-100g |
Abbexa |
100 µg |
EUR 337.5 |
Mouse Anti-Cow IgG1 Antibody |
|
abx401394-200g |
Abbexa |
200 µg |
EUR 400 |
 Mouse Anti-Pig IgG1 Antibody |
|
abx401399-100g |
Abbexa |
100 µg |
EUR 400 |
 Mouse Anti-Rat IgG1-PE |
|
MBS673733-01mg |
MyBiosource |
0.1mg |
EUR 325 |
Mouse Anti-Rat IgG1-PE |
|
MBS673733-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1315 |
 Mouse Anti-Rat IgG1-AP |
|
MBS673737-1mL |
MyBiosource |
1mL |
EUR 420 |
Mouse Anti-Rat IgG1-AP |
|
MBS673737-5x1mL |
MyBiosource |
5x1mL |
EUR 1740 |
Mouse Anti-Rat IgG1-PE |
|
MBS673740-01mg |
MyBiosource |
0.1mg |
EUR 325 |
Mouse Anti-Rat IgG1-PE |
|
MBS673740-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1315 |
 MOUSE ANTI BOVINE IgG1:HRP |
|
MBS219456-025mg |
MyBiosource |
0.25mg |
EUR 570 |
MOUSE ANTI BOVINE IgG1:HRP |
|
MBS219456-5x025mg |
MyBiosource |
5x0.25mg |
EUR 2385 |
 Mouse Anti-Rat IgG1-HRP |
|
MBS673731-1mL |
MyBiosource |
1mL |
EUR 420 |
Mouse Anti-Rat IgG1-HRP |
|
MBS673731-5x1mL |
MyBiosource |
5x1mL |
EUR 1740 |
 Mouse Anti-Rat IgG1-CY5 |
|
MBS673734-01mg |
MyBiosource |
0.1mg |
EUR 430 |
Mouse Anti-Rat IgG1-CY5 |
|
MBS673734-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1795 |
Mouse Anti-Rat IgG1-HRP |
|
MBS673738-1mL |
MyBiosource |
1mL |
EUR 420 |
Mouse Anti-Rat IgG1-HRP |
|
MBS673738-5x1mL |
MyBiosource |
5x1mL |
EUR 1740 |
Mouse Anti-Rat IgG1-CY5 |
|
MBS673741-01mg |
MyBiosource |
0.1mg |
EUR 430 |
Mouse Anti-Rat IgG1-CY5 |
|
MBS673741-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1795 |
 Mouse anti-Human IgG1 Antibody |
|
abx401124-05mg |
Abbexa |
0.5 mg |
EUR 794.4 |
|
|
 Mouse Anti-Human IgG1 antibody |
|
STJ99560-100l |
St John's Laboratory |
100 µl |
EUR 214.8 |
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Description: Unconjugated Mouse monoclonal to Human IgG1 antibody |
Mouse Anti-Human IgG1 antibody |
|
STJ99560-1mL |
St John's Laboratory |
1 mL |
EUR 1438.8 |
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Description: Unconjugated Mouse monoclonal to Human IgG1 antibody |
 Mouse Anti-Human IgG1 Antibody |
|
abx401124-100g |
Abbexa |
100 µg |
EUR 550 |
 Mouse Anti-Rat IgG1-UNLB |
|
MBS673729-05mg |
MyBiosource |
0.5mg |
EUR 290 |
Mouse Anti-Rat IgG1-UNLB |
|
MBS673729-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1155 |
 Mouse Anti-Rat IgG1-FITC |
|
MBS673730-05mg |
MyBiosource |
0.5mg |
EUR 345 |
Mouse Anti-Rat IgG1-FITC |
|
MBS673730-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1395 |
 Mouse Anti-Rat IgG1-BIOT |
|
MBS673732-05mg |
MyBiosource |
0.5mg |
EUR 320 |
Mouse Anti-Rat IgG1-BIOT |
|
MBS673732-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1295 |
Mouse Anti-Rat IgG1-UNLB |
|
MBS673735-05mg |
MyBiosource |
0.5mg |
EUR 290 |
Mouse Anti-Rat IgG1-UNLB |
|
MBS673735-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1155 |
Mouse Anti-Rat IgG1-FITC |
|
MBS673736-05mg |
MyBiosource |
0.5mg |
EUR 345 |
Mouse Anti-Rat IgG1-FITC |
|
MBS673736-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1395 |
Mouse Anti-Rat IgG1-BIOT |
|
MBS673739-05mg |
MyBiosource |
0.5mg |
EUR 320 |
Mouse Anti-Rat IgG1-BIOT |
|
MBS673739-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1295 |
 UNLB mouse anti-Hamster IgG1 |
|
E16SHU409-500U |
EnoGene |
500 μg |
EUR 693.33 |
|
Description: Available in various conjugation types. |
 Mouse Anti-Hamster IgG1-PE |
|
MBS679290-01mg |
MyBiosource |
0.1mg |
EUR 365 |
Mouse Anti-Hamster IgG1-PE |
|
MBS679290-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1495 |
 Mouse Anti-Hamster IgG1-HRP |
|
MBS675042-1mL |
MyBiosource |
1mL |
EUR 285 |
Mouse Anti-Hamster IgG1-HRP |
|
MBS675042-5x1mL |
MyBiosource |
5x1mL |
EUR 1135 |
) Goat anti Mouse IgG1 (Alk Phos) |
|
43R-IG058alk |
Fitzgerald |
500 ug |
EUR 304 |
|
|
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Description: Goat anti Mouse IgG1 secondary antibody (Alk Phos) |
 GOAT ANTI MOUSE IgG1:Alk. Phos. |
|
MBS235404-1mL |
MyBiosource |
1mL |
EUR 370 |
GOAT ANTI MOUSE IgG1:Alk. Phos. |
|
MBS235404-5x1mL |
MyBiosource |
5x1mL |
EUR 1500 |
Goat anti Mouse IgG1 (Alk Phos) |
|
MBS539105-05mg |
MyBiosource |
0.5mg |
EUR 565 |
Goat anti Mouse IgG1 (Alk Phos) |
|
MBS539105-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2385 |
 Biotin mouse anti-Hamster IgG1 |
|
E16SHB409-500U |
EnoGene |
500 μg |
EUR 715 |
|
Description: Available in various conjugation types. |
 Mouse Anti-Hamster IgG1-UNLB |
|
MBS675037-05mg |
MyBiosource |
0.5mg |
EUR 275 |
Mouse Anti-Hamster IgG1-UNLB |
|
MBS675037-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1075 |
 Mouse Anti-Hamster IgG1-BIOT |
|
MBS675050-05mg |
MyBiosource |
0.5mg |
EUR 275 |
Our analyses rejected the hypothesis of contemporary hybridization but revealed past introgression in the area where the distributions of the two species overlap. Overall, these results point to a scenario of historical gene flow after secondary contact followed by the evolution of reproductive isolation that currently prevents hybridization among sympatric populations.
