Genomics models in radiotherapy: From mechanistic to machine learning.

Machine learning (ML) provides a broad framework for addressing high-dimensional prediction problems in classification and regression. While ML is often applied for imaging problems in medical physics, there are many efforts to apply these principles to biological data toward questions of radiation biology.

Here, we provide a review of radiogenomics modeling frameworks and efforts toward genomically guided radiotherapy. We first discuss medical oncology efforts to develop precision biomarkers. We next discuss similar efforts to create clinical assays for normal tissue or tumor radiosensitivity. We then discuss modeling frameworks for radiosensitivity and the evolution of ML to create predictive models for radiogenomics.

Genomic footprints of an old affair: SNP data reveal historical hybridization and the subsequent evolution of reproductive barriers in two recently diverged grasshoppers with partly overlapping distributions.

Secondary contact in close relatives can result in hybridization and the admixture of previously isolated gene pools. However, after an initial period of hybridization, reproductive isolation can evolve through different processes and lead to the interruption of gene flow and the completion of the speciation process. Omocestus minutissimus and O. uhagonii are two closely related grasshoppers with partially overlapping distributions in the Central System mountains of the Iberian Peninsula.

To analyse spatial patterns of historical and/or contemporary hybridization between these two taxa and understand how species boundaries are maintained in the region of secondary contact, we sampled sympatric and allopatric populations of the two species and obtained genome-wide SNP data using a restriction site-associated DNA sequencing approach. We used Bayesian clustering analyses to test the hypothesis of contemporary hybridization in sympatric populations and employed a suite of phylogenomic approaches and a coalescent-based simulation framework to evaluate alternative hypothetical scenarios of interspecific gene flow.

Goat anti Mouse IgG1

FNSA-0086 500 uL
EUR 367.92
Description: Goat anti Mouse IgG1 secondary antibody

Rabbit anti Mouse IgG1

41C-CB5120 1 mg
EUR 302
Description: Rabbit anti Mouse IgG1 secondary antibody

Mouse anti Rat IgG1

41R-1117 100 ug
EUR 218
Description: Mouse anti Rat IgG1 secondary antibody

Mouse anti Human IgG1

10-I21A 200 ug
EUR 429
Description: Mouse anti Human IgG1 antibody

Mouse anti Human IgG1

10R-I110a 1 ml
EUR 1990
Description: Mouse anti Human IgG1 antibody

Mouse anti Human IgG1

10R-I127a 1 mg
EUR 429
Description: Mouse anti Human IgG1 antibody

Goat anti Mouse IgG1 (HRP)

43R-IG060hrp 1 mg
EUR 457.2
Description: Goat anti Mouse IgG1 secondary antibody (HRP)

Goat anti Mouse IgG1 (FITC)

43R-1648 1 mg
EUR 324
Description: Goat anti Mouse IgG1 secondary antibody (FITC)

Rabbit anti Mouse IgG1 (HRP)

43R-IR009HRP 1 mg
EUR 406.8
Description: Rabbit anti Mouse IgG1 secondary antibody (HRP)

Rabbit anti Mouse IgG1 (FITC)

43C-CB1521 1 mg
EUR 351
Description: Rabbit anti Mouse IgG1 secondary antibody (FITC)

Rabbit anti Mouse IgG1 (biotin)

43C-CB5124 1 mg
EUR 355
Description: Rabbit anti Mouse IgG1 secondary antibody (biotin)

Rabbit anti Mouse IgG1 (biotin)

43R-IR008bt 1 mg
EUR 355
Description: Rabbit anti Mouse IgG1 secondary antibody (biotin)

Rabbit anti Mouse IgG1 (rhodamine)

43C-CB5122 1 mg
EUR 355
Description: Rabbit anti Mouse IgG1 secondary antibody (Rhodamine)

Mouse anti Rat IgG1 (HRP)

43R-1582 100 ug
EUR 233
Description: Mouse anti Rat IgG1 antibody (HRP)

Mouse anti Human IgG1 (HRP)

43-1003 1 ml
EUR 263
Description: Mouse Anti-Human IgG1, Fc-HRP

Mouse anti-Cow IgG1 Antibody

abx401338-01mg 0.1 mg
EUR 543.6

Mouse anti-Cow IgG1 Antibody

abx401394-01mg 0.1 mg
EUR 610.8

Mouse anti-Pig IgG1 Antibody

abx401399-01mg 0.1 mg
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Mouse anti-Human IgG1 Antibody

abx401124-05mg 0.5 mg
EUR 794.4

Mouse Anti-Human IgG1 antibody

STJ99560-100l 100 µl
EUR 214.8
Description: Unconjugated Mouse monoclonal to Human IgG1 antibody

Mouse Anti-Human IgG1 antibody

STJ99560-1mL 1 mL
EUR 1438.8
Description: Unconjugated Mouse monoclonal to Human IgG1 antibody

UNLB mouse anti-Hamster IgG1

E16SHU409-500U 500 μg
EUR 693.33
Description: Available in various conjugation types.

Goat anti Mouse IgG1 (Alk Phos)

43R-IG058alk 500 ug
EUR 304
Description: Goat anti Mouse IgG1 secondary antibody (Alk Phos)

Biotin mouse anti-Hamster IgG1

E16SHB409-500U 500 μg
EUR 715
Description: Available in various conjugation types.

Rat anti Mouse IgG1 Heavy Chain

10R-I109b 1 mg
EUR 535
Description: Rat anti Mouse IgG1 Heavy Chain antibody

Rat anti Mouse IgG1 Heavy Chain

10R-I109c 1 mg
EUR 535
Description: Rat anti Mouse IgG1 Heavy Chain antibody

Rabbit anti Mouse IgG1 (Alk Phos)

43C-CB5126 1 mg
EUR 428
Description: Rabbit anti Mouse IgG1 secondary antibody (Alk Phos)

Goat anti Mouse IgG1 Antibody (HRP)

20-abx239824
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Monoclonal Mouse Anti-Human IgG1

C010215-10mg 10mg
EUR 2655.6

Monoclonal Mouse Anti-Human IgG1

C010215-1mg 1mg
EUR 525.6

Rabbit anti Mouse IgG1 (Texas Red)

43C-CB5123 1 mg
EUR 355
Description: Rabbit anti Mouse IgG1 secondary antibody

Rat Anti Mouse Igg1 Monoclonal Antibody

CABT-54553RM 1 mg
EUR 982.8

Goat Anti Mouse Igg1 Polyclonal Antibody

CPBT-68025GM 0.5 mg
EUR 696

Mouse anti-Cow IgG1 Antibody (HRP)

abx401339-025mg 0.25 mg
EUR 777.6

Mouse Anti-Human IgG1 (Fc) Antibody

abx023362-1mg 1 mg
EUR 811.2

Mouse Anti-Human IgG1 (Fc) Antibody

abx023375-05mg 0.5 mg
EUR 1045.2

Mouse Anti-Human IgG1 antibody (AU)

STJ99396-100l 100 µl
EUR 116.4
Description: AU conjugated Mouse monoclonal to Human IgG1

Mouse Anti-Human IgG1 antibody (AU)

STJ99396-1mL 1 mL
EUR 560.4
Description: AU conjugated Mouse monoclonal to Human IgG1

Mouse Anti-Human IgG1 antibody (HRP)

STJ99546-100l 100 µl
EUR 116.4
Description: HRP conjugated Mouse monoclonal to Human IgG1 antibody

Mouse Anti-Human IgG1 antibody (HRP)

STJ99546-1mL 1 mL
EUR 560.4
Description: HRP conjugated Mouse monoclonal to Human IgG1 antibody

Mouse Anti-Human IgG1 antibody (FITC)

STJ99496-100l 100 µl
EUR 116.4
Description: FITC conjugated Mouse monoclonal to Human IgG1

Mouse Anti-Human IgG1 antibody (FITC)

STJ99496-1mL 1 mL
EUR 560.4
Description: FITC conjugated Mouse monoclonal to Human IgG1

FITC/PE mouse IgG1/IgG1

E16FMCD001-020 20 tests
EUR 268.8
Description: Available in various conjugation types.

FITC/PE mouse IgG1/IgG1

E16FMCD001-050 50 tests
EUR 504
Description: Available in various conjugation types.

Mouse IgG1/IgG1, FITC/PE

E16MCD001-020 20 Tests
EUR 145
Description: Available in various conjugation types.

Mouse IgG1/IgG1, FITC/PE

E16MCD001-050 50 Tests
EUR 225
Description: Available in various conjugation types.

Mouse IgG1/IgG1 (FITC/PE)

E2790229 100ul
EUR 225
Description: Available in various conjugation types.

GOAT ANTI MOUSE IGG1, ANTISERA, 100 ML

7455530-100ML 1ML
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E16FMCT001-020 20 tests
EUR 336
Description: Available in various conjugation types.

FITC/PE/PE-Cy5 mouse IgG1/IgG1/IgG1

E16FMCT001-050 50 tests
EUR 604.8
Description: Available in various conjugation types.

Mouse IgG1/IgG1/IgG1, FITC/PE/PE-Cy5

E16MCT001-020 20 Tests
EUR 145
Description: Available in various conjugation types.

Mouse IgG1/IgG1/IgG1, FITC/PE/PE-Cy5

E16MCT001-050 50 Tests
EUR 255
Description: Available in various conjugation types.

Mouse IgG1/IgG1/IgG1 (FITC/PE/PE-Cy5)

E2790002 100ul
EUR 225
Description: Available in various conjugation types.

Mouse Anti Pig Igg1 Monoclonal Antibody

DMABT-52033MP 2 ml
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Mouse Anti-Human IgG1 antibody (Biotin)

STJ99446-100l 100 µl
EUR 116.4
Description: Biotin conjugated Mouse monoclonal to Human IgG1

Mouse Anti-Human IgG1 antibody (Biotin)

STJ99446-1mL 1 mL
EUR 560.4
Description: Biotin conjugated Mouse monoclonal to Human IgG1

GOAT ANTI MOUSE IGG1, ANTISERA, 1 LTR

7455530-1LTR 1LTR
EUR 1274.98

Goat anti Mouse IgG1 (Alexa Fluor 488)

43R-1649 500 ug
EUR 585
Description: Goat anti Mouse IgG1 secondary antibody (Alexa Fluor 488)

Mouse Anti Human Igg1 Monoclonal Antibody

CABT-48868MH 0.5 mg
EUR 670.8

HRP*Monoclonal Mouse Anti- Human IgG1

C030248-10ml 10ml
EUR 3162

HRP*Monoclonal Mouse Anti- Human IgG1

C030248-1ml 1ml
EUR 525.6

Mouse IgG1 Antibody

GWB-DD501D 1 mg Ask for price

Mouse IgG1 Antibody

IgG-001 1000 µg
EUR 588
Description: This antibody is purified from culture supernatant of a hybridoma (mouse myeloma fused with spleen cells from a mouse, clone APR-MP21) with protein A/G.

Mouse IgG1 Antibody

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Mouse IgG1 Antibody

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Mouse IgG1 Antibody

R20164-100UG 100ug
EUR 347.65
Description: This recombinant Mouse IgG1 antibody reacts to the Fc region of mouse IgG1. No cross reactivity with IgG2a, IgG3, IgM, IgA, IgE, human IgG, or rat IgG. It may slightly cross react to mIgG2b, and may also react to goat IgG.

Mouse IgG1 Antibody

R20164BTN-50UG 50ug
EUR 347.65
Description: This recombinant Mouse IgG1 antibody reacts to the Fc region of mouse IgG1. No cross reactivity with mouse IgG2a, IgG3, IgM, IgA, IgE, human IgG, or rat IgG. It may slightly cross react to mouse IgG2b, and may also react to goat IgG.

Mouse IgG1 Antibody

R20164SAF-250UG 250ug
EUR 832.15
Description: This recombinant Mouse IgG1 antibody reacts to the Fc region of mouse IgG1. No cross reactivity with IgG2a, IgG3, IgM, IgA, IgE, human IgG, or rat IgG. It may slightly cross react to mIgG2b, and may also react to goat IgG.

Mouse Anti Bovine Igg1 Monoclonal Antibody

DMABT-51905MB 0.25 mg
EUR 889.2

Mouse Anti Bovine Igg1 Monoclonal Antibody

DMABT-51906MB 2 ml
EUR 889.2

Anti- Immunoglobulin G1 (IgG1) Mouse Antibody

GWB-8D4B66 1 mg Ask for price

FITC*Monoclonal Mouse Anti- Human IgG1

C030648-10ml 10ml
EUR 3162

FITC*Monoclonal Mouse Anti- Human IgG1

C030648-1ml 1ml
EUR 525.6

Rat anti Mouse IgG1 Kappa Light Chain

10R-K103a 1 mg
EUR 535
Description: Rat anti Mouse IgG1 Kappa Light Chain antibody

Rat anti Mouse IgG1 Heavy Chain (biotin)

61R-I109bBT 1 mg
EUR 623
Description: Rat anti Mouse IgG1 Heavy Chain antibody (biotin)

Rat anti Mouse IgG1 Heavy Chain (biotin)

61R-I109cBT 1 mg
EUR 623
Description: Rat anti Mouse IgG1 Heavy Chain antibody (biotin)

BIOTIN*Monoclonal Mouse Anti- Human IgG1

C030848-10ml 10ml
EUR 2148

BIOTIN*Monoclonal Mouse Anti- Human IgG1

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EUR 424.8

Anti-MERS-CoV S1 Mouse IgG1 Antibody

A2065-100 100 µg
EUR 381.6

Anti-SARS-CoV NP Mouse IgG1 Antibody

A2066-100 100 µg
EUR 381.6

Goat Anti Mouse Igg1 Polyclonal Antibody,HRP

CPBT-68024GM 1 ml
EUR 696

Mouse Anti-MMAE Antibody, Mouse IgG1 (MALS verified)

MME-M5252 100ug
EUR 2140
Description: Mouse Anti-MMAE Antibody, is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with MMAE.

Goat Anti Mouse Igg1 Polyclonal Antibody,FITC

CPBT-68023GM 0.5 mg
EUR 696

Rabbit Anti Mouse Igg1 Polyclonal Antibody,HRP

CPBT-68016RM 1 mg
EUR 1132.8

Anti-Human IL15 (9B5G1) mAb, Mouse IgG1

IL5-M543 1mg
EUR 321
Description: Anti-Human IL15 (9B5G1) MAb, Mouse IgG1 is a monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which combines the variable region of a Mouse monoclonal antibody with mouse IgG1 constant domain. The mouse monoclonal antibody is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with IL15.

Mouse IgG1

31C-CH1004 1 mg
EUR 373
Description: Purified Mouse IgG1

Mouse IgG1

C040307-10mg 10mg
EUR 2148

Mouse IgG1

C040307-1mg 1mg
EUR 728.4

Mouse monoclonal Anti-Bovine IgG1, purified

80654-U 100 ug
EUR 489.6

Anti-Human IL15 (12B11E5) mAb, Mouse IgG1

IL5-M542 1mg
EUR 321
Description: Anti-Human IL15 (12B11E5) MAb, Mouse IgG1 is a monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which combines the variable region of a Mouse monoclonal antibody with mouse IgG1 constant domain. The mouse monoclonal antibody is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with IL15.

Goat Anti Mouse IgG1 Polyclonal Affinity Purified

IGTAMSIGG1AP1MG each
EUR 308
Description: Goat Anti Mouse IgG1 Polyclonal Affinity Purified

Mouse Anti-LPS IgG1 Antibody Assay kit

6107 1 kit
EUR 377
Description: Serum, Plasma

Mouse Anti-SEB IgG1 Antibody Assay Kit

6215 1 kit
EUR 377
Description: Serum, Plasma

Mouse Anti-SEA IgG1 Antibody Assay Kit

6219 1 kit
EUR 377
Description: Serum, Plasma

Monoclonal Anti-IFNγ Antibody, Mouse IgG1 (13E6H6)

IFN-S138 100ug
EUR 2140
Description: Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.

FITC-Labeled Anti-Rituximab Antibody, Mouse IgG1

RIB-FY35c 25ug
EUR 2354
Description: FITC-Labeled Anti-Rituximab Antibodies, Mouse IgG1 (RIB-FY35c) are expressed from human 293 cells (HEK293).

Mouse anti-Rat IgG1 Heavy Chain Antibody

abx401319-025mg 0.25 mg
EUR 678

Anti-6xHis(Mouse IgG1-κ), Monoclonal(HI192), AS

04428-26 50UG
EUR 105

Anti-6xHis(Mouse IgG1-κ), Monoclonal(HI192), AS

04428-84 200UG
EUR 315

Anti-V5(Mouse IgG1-κ), Monoclonal(V5005), AS

04434-36 200UG
EUR 315

Anti-V5(Mouse IgG1-κ), Monoclonal(V5005), AS

04434-94 50UG
EUR 105

Anti-HA(Mouse IgG1-κ), Monoclonal(HA124), AS

06340-54 200UG
EUR 196

Anti-HA(Mouse IgG1-κ), Monoclonal(HA124), AS

06340-96 50UG
EUR 66.5

Mouse Anti-Gliadin IgG1 Antibody Assay Kit

3052 1 kit
EUR 404
Description: Serum, Plasma

Mouse Anti Human Igg1 (Fc) Monoclonal Antibody

CABT-48867MH 0.2 mg
EUR 982.8

Anti-Cortisol antibody *Mouse anti-human, monoclonal IgG1*

V100220 50 ug
EUR 367.2

Anti-Cortisol antibody *Mouse anti-human, monoclonal IgG1*

V100221 1 mg
EUR 889.2

Anti-GFP(Mouse IgG1-κ), Monoclonal(GF200), AS

04363-24 200UG
EUR 322

Anti-GFP(Mouse IgG1-κ), Monoclonal(GF200), AS

04363-66 50UG
EUR 107.1

Anti-Estradiol antibody *Mouse anti-human, monoclonal IgG1*

V100185 50 ug
EUR 367.2

Anti-Estradiol antibody *Mouse anti-human, monoclonal IgG1*

V100186 1 mg
EUR 680.4

Anti-Kanamycin antibody *Mouse anti-human, monoclonal IgG1*

V100265 50 ug
EUR 367.2

Anti-Kanamycin antibody *Mouse anti-human, monoclonal IgG1*

V100266 1 mg
EUR 1306.8

Mouse Anti Bovine Igg1 Monoclonal Antibody,HRP

DMABT-51904MB 0.25 mg
EUR 889.2

Anti-Gentamicin antibody *Mouse anti-human, monoclonal IgG1*

V100270 50 ug
EUR 367.2

Anti-Gentamicin antibody *Mouse anti-human, monoclonal IgG1*

V100271 1 mg
EUR 1306.8

Anti-Ractopamine antibody *Mouse anti-human, monoclonal IgG1*

V100240 50 ug
EUR 367.2

Anti-Ractopamine antibody *Mouse anti-human, monoclonal IgG1*

V100241 1 mg
EUR 889.2

Anti-Clenbuterol antibody *Mouse anti-human, monoclonal IgG1*

V100245 50 ug
EUR 367.2

Anti-Clenbuterol antibody *Mouse anti-human, monoclonal IgG1*

V100246 1 mg
EUR 889.2

Mouse IgG1 (FITC) / Mouse IgG1 (RPE) Isotype Control

abx405001-50tests 50 tests
EUR 760.8

Mouse IgG1 (FITC) / Mouse IgG1 (RPE) Isotype Control

abx405005-100tests 100 tests
EUR 744

Rat anti Mouse IgG1 Kappa Light Chain (biotin)

61R-K103aBT 1 mg
EUR 623
Description: Rat anti Mouse IgG1 Kappa Light Chain antibody (biotin)

PE anti-mouse IgG1

E16SHP501-050U 50 μg
EUR 390
Description: Available in various conjugation types.

PE anti-mouse IgG1

E16SHP501-200U 200 μg
EUR 1148.33
Description: Available in various conjugation types.

MOUSE IgG1:FITC/MOUSE IgG1:RPE NEGATIVE CONTROL

GWB-2BA353 50 TESTS Ask for price

MOUSE IgG1:FITC/MOUSE IgG1:RPE NEGATIVE CONTROL

GWB-AA514A 100 TESTS Ask for price

Anti-Thyroglobulin antibody *Mouse anti-human, monoclonal IgG1*

V100155 50 ug
EUR 367.2

Anti-Thyroglobulin antibody *Mouse anti-human, monoclonal IgG1*

V100156 1 mg
EUR 889.2

Anti-Furazolidone antibody *Mouse anti-human, monoclonal IgG1*

V100250 50 ug
EUR 367.2

Our analyses rejected the hypothesis of contemporary hybridization but revealed past introgression in the area where the distributions of the two species overlap. Overall, these results point to a scenario of historical gene flow after secondary contact followed by the evolution of reproductive isolation that currently prevents hybridization among sympatric populations.