The gut contains an enormous diversity of simple as well as complex molecules from highly diverse food sources, together with host-secreted molecules. This presents a large metabolic opportunity for the gut microbiota, but little is known about how gut microbes are able to catabolize this large chemical diversity. Recently, Fe-S flavoenzymes were found to be key in the transformation of bile acids, catalysing the key step in the 7α-dehydroxylation pathway that allows gut bacteria to transform cholic acid into deoxycholic acid, an exclusively microbe-derived molecule with major implications for human health.
While this enzyme family has also been implicated in a limited number of other catalytic transformations, little is known about the extent to which it is of more global importance in gut microbial metabolism. Here, we perform a large-scale computational genomic analysis to show that this enzyme superfamily has undergone a remarkable expansion in Clostridiales, and occurs throughout a diverse array of >1000 different families of putative metabolic gene clusters. Analysis of the enzyme content of these gene clusters suggests that they encode pathways with a wide range of predicted substrate classes, including saccharides, amino acids/peptides and lipids.
Altogether, these results indicate a potentially important role of this protein superfamily in the human gut, and our dataset provides significant opportunities for the discovery of novel pathways that may have significant effects on human health.
Rat anti Mouse IgG2a |
MBS531265-5x1mg |
MyBiosource |
5x1mg |
EUR 3950 |
Goat anti Mouse IgG2a |
41R-1128 |
Fitzgerald |
1 mg |
EUR 331 |
|
Description: Goat anti Mouse IgG2a secondary antibody |
Goat anti Mouse IgG2a |
FNSA-0087 |
FN Test |
500 uL |
EUR 367.92 |
|
Description: Goat anti Mouse IgG2a secondary antibody |
GOAT ANTI MOUSE IgG2a |
MBS235408-05mg |
MyBiosource |
0.5mg |
EUR 265 |
GOAT ANTI MOUSE IgG2a |
MBS235408-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1020 |
Rabbit anti Mouse IgG2a |
41C-CB5127 |
Fitzgerald |
1 mg |
EUR 302 |
|
Description: Rabbit anti Mouse IgG2a secondary antibody |
Rabbit anti Mouse IgG2a |
MBS539829-1mg |
MyBiosource |
1mg |
EUR 540 |
Rabbit anti Mouse IgG2a |
MBS539829-5x1mg |
MyBiosource |
5x1mg |
EUR 2280 |
Mouse anti Rat IgG2a |
41R-1118 |
Fitzgerald |
100 ug |
EUR 218 |
|
Description: Mouse anti Rat IgG2a secondary antibody |
Goat anti Mouse IgG2a (HRP) |
43R-IG064hrp |
Fitzgerald |
1 ml |
EUR 422 |
|
Description: Goat anti Mouse IgG2a secondary antibody (HRP) |
Goat anti Mouse IgG2a (HRP) |
MBS539084-1mg |
MyBiosource |
1mg |
EUR 675 |
Goat anti Mouse IgG2a (HRP) |
MBS539084-5x1mg |
MyBiosource |
5x1mg |
EUR 2880 |
Goat anti Mouse IgG2a (FITC) |
43R-IG063ft |
Fitzgerald |
1 ml |
EUR 369 |
|
Description: Goat anti Mouse IgG2a secondary antibody (FITC) |
Goat anti Mouse IgG2a (FITC) |
MBS539072-1mg |
MyBiosource |
1mg |
EUR 645 |
Goat anti Mouse IgG2a (FITC) |
MBS539072-5x1mg |
MyBiosource |
5x1mg |
EUR 2755 |
Rat anti Mouse IgG2a (biotin) |
61R-I117bBT |
Fitzgerald |
1 mg |
EUR 623 |
|
Description: Rat anti Mouse IgG2a antibody (biotin) |
Rat anti Mouse IgG2a (biotin) |
MBS530088-1mg |
MyBiosource |
1mg |
EUR 1050 |
Rat anti Mouse IgG2a (biotin) |
MBS530088-5x1mg |
MyBiosource |
5x1mg |
EUR 4580 |
Rabbit anti Mouse IgG2a (FITC) |
43C-CB5128 |
Fitzgerald |
1 mg |
EUR 351 |
|
Description: Rabbit anti Mouse IgG2a secondary antibody (FITC) |
Rabbit anti Mouse IgG2a (FITC) |
MBS539790-1mg |
MyBiosource |
1mg |
EUR 620 |
Rabbit anti Mouse IgG2a (FITC) |
MBS539790-5x1mg |
MyBiosource |
5x1mg |
EUR 2635 |
Anti-HA [8H5], Mouse IgG2a |
MBS488948-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-HA [8H5], Mouse IgG2a |
MBS488948-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
Rabbit anti Mouse IgG2a (biotin) |
43C-CB5131 |
Fitzgerald |
1 mg |
EUR 355 |
|
Description: Rabbit anti Mouse IgG2a secondary antibody (biotin) |
Rabbit anti Mouse IgG2a (biotin) |
MBS538766-1mg |
MyBiosource |
1mg |
EUR 620 |
Rabbit anti Mouse IgG2a (biotin) |
MBS538766-5x1mg |
MyBiosource |
5x1mg |
EUR 2635 |
Anti-SERT [8B6], Mouse IgG2a |
MBS488912-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-SERT [8B6], Mouse IgG2a |
MBS488912-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
Anti-CD123 [7G3], Mouse IgG2a |
MBS488955-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-CD123 [7G3], Mouse IgG2a |
MBS488955-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
Mouse anti Rat IgG2a (HRP) |
43R-1581 |
Fitzgerald |
100 ug |
EUR 233 |
|
Description: Mouse anti Rat IgG2a antibody (HRP) |
Rabbit anti Mouse IgG2a (rhodamine) |
43R-IR011rd |
Fitzgerald |
1 mg |
EUR 355 |
|
Description: Rabbit anti Mouse IgG2a secondary antibody (Rhodamine) |
Rabbit anti Mouse IgG2a (rhodamine) |
MBS539092-1mg |
MyBiosource |
1mg |
EUR 620 |
Rabbit anti Mouse IgG2a (rhodamine) |
MBS539092-5x1mg |
MyBiosource |
5x1mg |
EUR 2635 |
Anti-Normal Mouse IgG2a Antibody |
MBS4158477-01mg |
MyBiosource |
0.1mg |
EUR 1055 |
Anti-Normal Mouse IgG2a Antibody |
MBS4158477-5x01mg |
MyBiosource |
5x0.1mg |
EUR 4485 |
Mouse Anti-Rat IgG2a-AP |
MBS673744-1mL |
MyBiosource |
1mL |
EUR 420 |
Mouse Anti-Rat IgG2a-AP |
MBS673744-5x1mL |
MyBiosource |
5x1mL |
EUR 1740 |
Mouse Anti-Rat IgG2a-PE |
MBS673747-01mg |
MyBiosource |
0.1mg |
EUR 325 |
Mouse Anti-Rat IgG2a-PE |
MBS673747-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1315 |
Mouse Anti-Rat IgG2a-HRP |
MBS673745-1mL |
MyBiosource |
1mL |
EUR 420 |
Mouse Anti-Rat IgG2a-HRP |
MBS673745-5x1mL |
MyBiosource |
5x1mL |
EUR 1740 |
Mouse Anti-Rat IgG2a-CY5 |
MBS673748-01mg |
MyBiosource |
0.1mg |
EUR 430 |
Mouse Anti-Rat IgG2a-CY5 |
MBS673748-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1795 |
Mouse Anti-Rat IgG2a-UNLB |
MBS673742-05mg |
MyBiosource |
0.5mg |
EUR 290 |
Mouse Anti-Rat IgG2a-UNLB |
MBS673742-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1155 |
Mouse Anti-Rat IgG2a-FITC |
MBS673743-05mg |
MyBiosource |
0.5mg |
EUR 345 |
Mouse Anti-Rat IgG2a-FITC |
MBS673743-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1395 |
Mouse Anti-Rat IgG2a-BIOT |
MBS673746-05mg |
MyBiosource |
0.5mg |
EUR 320 |
Mouse Anti-Rat IgG2a-BIOT |
MBS673746-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1295 |
Anti-VEGF [Bevacizumab], Mouse IgG2a |
MBS488892-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-VEGF [Bevacizumab], Mouse IgG2a |
MBS488892-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
Goat anti Mouse IgG2a (Alk Phos) |
43R-IG062alk |
Fitzgerald |
1 ml |
EUR 304 |
|
Description: Goat anti Mouse IgG2a secondary antibody (Alk Phos) |
Goat anti Mouse IgG2a (Alk Phos) |
MBS539198-05mg |
MyBiosource |
0.5mg |
EUR 565 |
Goat anti Mouse IgG2a (Alk Phos) |
MBS539198-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2385 |
Rat anti Mouse IgG2a Heavy Chain |
10R-I115a |
Fitzgerald |
1 mg |
EUR 535 |
|
Description: Rat anti Mouse IgG2a Heavy Chain antibody |
Rabbit anti Mouse IgG2a (Alk Phos) |
43C-CB5133 |
Fitzgerald |
1 mg |
EUR 428 |
|
Description: Rabbit anti Mouse IgG2a secondary antibody (Alk Phos) |
RAT ANTI MOUSE IgG2a HEAVY CHAIN |
MBS235047-025mg |
MyBiosource |
0.25mg |
EUR 490 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN |
MBS235047-5x025mg |
MyBiosource |
5x0.25mg |
EUR 2025 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN |
MBS212237-1mg |
MyBiosource |
1mg |
EUR 755 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN |
MBS212237-5x1mg |
MyBiosource |
5x1mg |
EUR 3220 |
Rat anti Mouse IgG2a Heavy Chain |
MBS530830-1mg |
MyBiosource |
1mg |
EUR 910 |
Rat anti Mouse IgG2a Heavy Chain |
MBS530830-5x1mg |
MyBiosource |
5x1mg |
EUR 3950 |
Rabbit anti Mouse IgG2a (Alk Phos) |
MBS538768-1mg |
MyBiosource |
1mg |
EUR 745 |
Rabbit anti Mouse IgG2a (Alk Phos) |
MBS538768-5x1mg |
MyBiosource |
5x1mg |
EUR 3210 |
Goat anti Mouse IgG2a Antibody (HRP) |
20-abx239825 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
Rabbit anti Mouse IgG2a (Texas Red) |
43C-CB5125 |
Fitzgerald |
1 mg |
EUR 355 |
|
Description: Rabbit anti Mouse IgG2a secondary antibody |
RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP |
MBS235030-05mg |
MyBiosource |
0.5mg |
EUR 695 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP |
MBS235030-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2960 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP |
MBS211164-05mg |
MyBiosource |
0.5mg |
EUR 640 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP |
MBS211164-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2710 |
Rabbit anti Mouse IgG2a (Texas Red) |
MBS538763-1mg |
MyBiosource |
1mg |
EUR 620 |
Rabbit anti Mouse IgG2a (Texas Red) |
MBS538763-5x1mg |
MyBiosource |
5x1mg |
EUR 2635 |
Anti-CD8 [G10-1], Mouse IgG2a |
MBS488906-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-CD8 [G10-1], Mouse IgG2a |
MBS488906-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC |
MBS235021-05mg |
MyBiosource |
0.5mg |
EUR 695 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC |
MBS235021-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2960 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC |
MBS210741-05mg |
MyBiosource |
0.5mg |
EUR 640 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC |
MBS210741-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2710 |
Anti-NK1.1 [PK-136], Mouse IgG2a |
MBS488969-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-NK1.1 [PK-136], Mouse IgG2a |
MBS488969-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN:Biotin |
MBS235009-05mg |
MyBiosource |
0.5mg |
EUR 695 |
RAT ANTI MOUSE IgG2a HEAVY CHAIN:Biotin |
MBS235009-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2960 |
Anti-CD18 [1B4], Mouse IgG2a, Kappa |
MBS488524-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-CD18 [1B4], Mouse IgG2a, Kappa |
MBS488524-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
Mouse anti-OVA IgG2a (OVA IgG2a) quantitative detection ELISA Kit |
MBS3809955-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6545 |
Mouse anti-OVA IgG2a (OVA IgG2a) quantitative detection ELISA Kit |
MBS3809955-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3325 |
Mouse anti-OVA IgG2a (OVA IgG2a) quantitative detection ELISA Kit |
MBS3809955-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 720 |
Goat anti Mouse IgG2a (subclass specific) |
MBS571897-10mg |
MyBiosource |
10mg |
EUR 715 |
Goat anti Mouse IgG2a (subclass specific) |
MBS571897-5x10mg |
MyBiosource |
5x10mg |
EUR 3080 |
Goat anti Mouse IgG2a (subclass specific) |
MBS571903-1mL |
MyBiosource |
1mL |
EUR 365 |
Goat anti Mouse IgG2a (subclass specific) |
MBS571903-5x1mL |
MyBiosource |
5x1mL |
EUR 1490 |
Goat Anti Mouse Igg2a Polyclonal Antibody |
CPBT-68030GM |
Creative Diagnostics |
0.5 mg |
EUR 540.54 |
Description: Goat |
Sheep anti Mouse IgG2a (subclass specific) |
MBS571586-1mL |
MyBiosource |
1mL |
EUR 365 |
Sheep anti Mouse IgG2a (subclass specific) |
MBS571586-5x1mL |
MyBiosource |
5x1mL |
EUR 1490 |
Anti-CD41 [7E3 (Abciximab)], Mouse IgG2a |
MBS488880-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-CD41 [7E3 (Abciximab)], Mouse IgG2a |
MBS488880-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
Mouse Anti-Rat IgG2a H Antibody |
abx401351-100g |
Abbexa |
100 µg |
Ask for price |
Mouse Anti-Rat IgG2a H Antibody |
abx401351-500g |
Abbexa |
500 µg |
Ask for price |
Mouse Anti-Rat IgG2a H Antibody |
abx401351-50g |
Abbexa |
50 µg |
EUR 450 |
Rabbit anti Mouse IgG2a (subclass specific) |
MBS571569-1mL |
MyBiosource |
1mL |
EUR 365 |
Rabbit anti Mouse IgG2a (subclass specific) |
MBS571569-5x1mL |
MyBiosource |
5x1mL |
EUR 1490 |
MOUSE ANTI RAT IgG2a HEAVY CHAIN |
MBS235044-025mg |
MyBiosource |
0.25mg |
EUR 490 |
MOUSE ANTI RAT IgG2a HEAVY CHAIN |
MBS235044-5x025mg |
MyBiosource |
5x0.25mg |
EUR 2025 |
Monoclonal Anti-PBD Antibody, Mouse IgG2a |
PBD-S397 |
ACROBIOSYSTEMS |
1mg |
EUR 381.5 |
|
Description: Pyrrole benzodiazepine dimers (pyrololobenzodiazepine, PBD) A novel class of antibody-drug conjugates (ADCs) that produce highly cytotoxic DNA cross-linking, Completely different cellular targets were utilized to inhibit aurisatin and maytansinoid tubulin and produce different patterns of DNA damage to other DNA-interacting warheads, such as calicheamicin. For example, Zynlonta is a human-derived CD19-targeting ADC that is coupled to a pyrrole benzodiazepine (PBD) dimer toxin. When PBD dimer enters a cell, it specifically binds to DNA, forming effective cytotoxic DNA crosslinking that stops cell division and kills cancer cells. Among them, CD19 is a specific antigen expressed on the surface of B cells and is the target of multiple CAR-T therapies. |
MOUSE ANTI RAT IgG2a HEAVY CHAIN:HRP |
MBS235027-05mg |
MyBiosource |
0.5mg |
EUR 1000 |
MOUSE ANTI RAT IgG2a HEAVY CHAIN:HRP |
MBS235027-5x05mg |
MyBiosource |
5x0.5mg |
EUR 4315 |
Mouse IgG2a |
31C-CH1007 |
Fitzgerald |
1 mg |
EUR 373 |
|
Description: Purified Mouse IgG2a |
Mouse IgG2a |
CE40308-10mg |
Unibiotest |
10 mg |
EUR 2000 |
Mouse IgG2a |
MBS666886-5x01mg |
MyBiosource |
5x0.1mg |
EUR 3100 |
Mouse IgG2a |
MBS666889-5x01mg |
MyBiosource |
5x0.1mg |
EUR 3100 |
Anti-CD20 [10F381 (rituximab)], Mouse IgG2a |
MBS488874-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-CD20 [10F381 (rituximab)], Mouse IgG2a |
MBS488874-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
Anti-RSV [RSHZ19 (Felvizumab)], Mouse IgG2a |
MBS488897-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-RSV [RSHZ19 (Felvizumab)], Mouse IgG2a |
MBS488897-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
Mouse IgG2a Antibody |
IgG-002 |
ReliaTech |
1000 µg |
EUR 588 |
Description: This antibody is purified from culture supernatant of a hybridoma (mouse myeloma fused with spleen cells from a mouse, clone APR-C184) with protein A/G. |
Mouse IgG2a Antibody |
R20166SAF-250UG |
NSJ Bioreagents |
250ug |
EUR 832.15 |
|
Description: This recombinant Mouse IgG2a antibody reacts to the Fc region of mIgG2a. No cross reactivity with mouse IgG1, IgG2b, IgG2c, IgG3, IgM, IgA, IgE, human/rat IgG. |
MOUSE ANTI RAT IgG2a HEAVY CHAIN:FITC |
MBS235018-05mg |
MyBiosource |
0.5mg |
EUR 640 |
MOUSE ANTI RAT IgG2a HEAVY CHAIN:FITC |
MBS235018-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2710 |
Anti-CD40L [hu5c8 (Ruplizumab)], Mouse IgG2a |
MBS488882-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-CD40L [hu5c8 (Ruplizumab)], Mouse IgG2a |
MBS488882-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
Anti-CD11a [hu1124 (Efalizumab)], Mouse IgG2a |
MBS488888-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-CD11a [hu1124 (Efalizumab)], Mouse IgG2a |
MBS488888-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
MOUSE ANTI RAT IgG2a HEAVY CHAIN:Biotin |
MBS235006-05mg |
MyBiosource |
0.5mg |
EUR 640 |
MOUSE ANTI RAT IgG2a HEAVY CHAIN:Biotin |
MBS235006-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2710 |
Mouse IgG2a (FITC) / Mouse IgG2a (PE) Isotype Control |
abx405002-100g |
Abbexa |
100 µg |
EUR 500 |
Mouse IgG2a (FITC) / Mouse IgG2a (RPE) Isotype Control |
abx405002-50tests |
Abbexa |
50 tests |
EUR 744 |
|
Anti-IL-16 [14.1], Mouse IgG2a, Kappa |
MBS488510-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-IL-16 [14.1], Mouse IgG2a, Kappa |
MBS488510-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
Anti-IL-5 [2E3], Mouse IgG2a, Kappa |
MBS488517-02mg |
MyBiosource |
0.2mg |
EUR 520 |
Anti-IL-5 [2E3], Mouse IgG2a, Kappa |
MBS488517-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2160 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807057-01mg |
MyBiosource |
0.1mg |
EUR 490 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807057-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1935 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807062-01mg |
MyBiosource |
0.1mg |
EUR 485 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807062-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1925 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807066-01mg |
MyBiosource |
0.1mg |
EUR 480 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807066-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1905 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807106-01mg |
MyBiosource |
0.1mg |
EUR 435 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807106-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1700 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807127-01mg |
MyBiosource |
0.1mg |
EUR 480 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807127-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1915 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807276-01mg |
MyBiosource |
0.1mg |
EUR 490 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807276-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1940 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807282-01mg |
MyBiosource |
0.1mg |
EUR 475 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807282-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1885 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807315-01mg |
MyBiosource |
0.1mg |
EUR 490 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807315-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1945 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807316-01mg |
MyBiosource |
0.1mg |
EUR 485 |
Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
MBS807316-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1920 |
Rat anti Mouse IgG2a Heavy Chain (biotin) |
61R-I115aBT |
Fitzgerald |
1 mg |
EUR 623 |
|
Description: Rat anti Mouse IgG2a Heavy Chain antibody (biotin) |
Rat anti Mouse IgG2a Heavy Chain (biotin) |
MBS530926-1mg |
MyBiosource |
1mg |
EUR 1050 |
Rat anti Mouse IgG2a Heavy Chain (biotin) |
MBS530926-5x1mg |
MyBiosource |
5x1mg |
EUR 4580 |
IgG2a, Mouse |
MBS654868-5x1mg |
MyBiosource |
5x1mg |
EUR 2795 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807332-01mg |
MyBiosource |
0.1mg |
EUR 485 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807332-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1920 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807336-01mg |
MyBiosource |
0.1mg |
EUR 490 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807336-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1945 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807358-01mg |
MyBiosource |
0.1mg |
EUR 440 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807358-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1705 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS806986-01mg |
MyBiosource |
0.1mg |
EUR 490 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS806986-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1940 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807024-01mg |
MyBiosource |
0.1mg |
EUR 490 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807024-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1945 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807052-01mg |
MyBiosource |
0.1mg |
EUR 485 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807052-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1925 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807124-01mg |
MyBiosource |
0.1mg |
EUR 480 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807124-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1910 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807249-01mg |
MyBiosource |
0.1mg |
EUR 485 |
Mouse Anti-Human PP5 Monoclonal IgG2a |
MBS807249-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1930 |
Anti-inflammatory glucocorticoid action: genomic insights and emerging concepts.
Glucocorticoids (GCs) are widely used immunomodulators. They regulate gene expression by binding and activating the Glucocorticoid Receptor (GR), but underlying transcriptional mechanisms remain enigmatic. This review summarizes recent findings identifyingspecific GR-bound DNA sequences whose configuration may affect transcriptional output.
Additional factors affecting GR’s anti-inflammatory actions, including different chromatin states such as DNAse hypersensitive regions and histone marks will be discussed, together with the relevant transcriptional co-regulators and promoter/enhancer features. Furthermore, the involvement of non-coding RNAs such as lncRNAs, miRNAs and eRNAs adds another level of regulation to the GR’s transcriptional activity. Characterizing and understanding these multiple mechanisms will be crucial for developing more targeted immunomodulatory therapies with reduced adverse effects such as obesity, diabetes and osteoporosis.