Computational genomic discovery of diverse gene clusters harbouring Fe-S flavoenzymes in anaerobic gut microbiota.

The gut contains an enormous diversity of simple as well as complex molecules from highly diverse food sources, together with host-secreted molecules. This presents a large metabolic opportunity for the gut microbiota, but little is known about how gut microbes are able to catabolize this large chemical diversity. Recently, Fe-S flavoenzymes were found to be key in the transformation of bile acids, catalysing the key step in the 7α-dehydroxylation pathway that allows gut bacteria to transform cholic acid into deoxycholic acid, an exclusively microbe-derived molecule with major implications for human health.

While this enzyme family has also been implicated in a limited number of other catalytic transformations, little is known about the extent to which it is of more global importance in gut microbial metabolism. Here, we perform a large-scale computational genomic analysis to show that this enzyme superfamily has undergone a remarkable expansion in Clostridiales, and occurs throughout a diverse array of >1000 different families of putative metabolic gene clusters. Analysis of the enzyme content of these gene clusters suggests that they encode pathways with a wide range of predicted substrate classes, including saccharides, amino acids/peptides and lipids.

Altogether, these results indicate a potentially important role of this protein superfamily in the human gut, and our dataset provides significant opportunities for the discovery of novel pathways that may have significant effects on human health.

Rat anti Mouse IgG2a

MBS531265-5x1mg 5x1mg
EUR 3950

Goat anti Mouse IgG2a

41R-1128 1 mg
EUR 331
Description: Goat anti Mouse IgG2a secondary antibody

Goat anti Mouse IgG2a

FNSA-0087 500 uL
EUR 367.92
Description: Goat anti Mouse IgG2a secondary antibody

GOAT ANTI MOUSE IgG2a

MBS235408-05mg 0.5mg
EUR 265

GOAT ANTI MOUSE IgG2a

MBS235408-5x05mg 5x0.5mg
EUR 1020

Rabbit anti Mouse IgG2a

41C-CB5127 1 mg
EUR 302
Description: Rabbit anti Mouse IgG2a secondary antibody

Rabbit anti Mouse IgG2a

MBS539829-1mg 1mg
EUR 540

Rabbit anti Mouse IgG2a

MBS539829-5x1mg 5x1mg
EUR 2280

Mouse anti Rat IgG2a

41R-1118 100 ug
EUR 218
Description: Mouse anti Rat IgG2a secondary antibody

Goat anti Mouse IgG2a (HRP)

43R-IG064hrp 1 ml
EUR 422
Description: Goat anti Mouse IgG2a secondary antibody (HRP)

Goat anti Mouse IgG2a (HRP)

MBS539084-1mg 1mg
EUR 675

Goat anti Mouse IgG2a (HRP)

MBS539084-5x1mg 5x1mg
EUR 2880

Goat anti Mouse IgG2a (FITC)

43R-IG063ft 1 ml
EUR 369
Description: Goat anti Mouse IgG2a secondary antibody (FITC)

Goat anti Mouse IgG2a (FITC)

MBS539072-1mg 1mg
EUR 645

Goat anti Mouse IgG2a (FITC)

MBS539072-5x1mg 5x1mg
EUR 2755

Rat anti Mouse IgG2a (biotin)

61R-I117bBT 1 mg
EUR 623
Description: Rat anti Mouse IgG2a antibody (biotin)

Rat anti Mouse IgG2a (biotin)

MBS530088-1mg 1mg
EUR 1050

Rat anti Mouse IgG2a (biotin)

MBS530088-5x1mg 5x1mg
EUR 4580

Rabbit anti Mouse IgG2a (FITC)

43C-CB5128 1 mg
EUR 351
Description: Rabbit anti Mouse IgG2a secondary antibody (FITC)

Rabbit anti Mouse IgG2a (FITC)

MBS539790-1mg 1mg
EUR 620

Rabbit anti Mouse IgG2a (FITC)

MBS539790-5x1mg 5x1mg
EUR 2635

Anti-HA [8H5], Mouse IgG2a

MBS488948-02mg 0.2mg
EUR 520

Anti-HA [8H5], Mouse IgG2a

MBS488948-5x02mg 5x0.2mg
EUR 2160

Rabbit anti Mouse IgG2a (biotin)

43C-CB5131 1 mg
EUR 355
Description: Rabbit anti Mouse IgG2a secondary antibody (biotin)

Rabbit anti Mouse IgG2a (biotin)

MBS538766-1mg 1mg
EUR 620

Rabbit anti Mouse IgG2a (biotin)

MBS538766-5x1mg 5x1mg
EUR 2635

Anti-SERT [8B6], Mouse IgG2a

MBS488912-02mg 0.2mg
EUR 520

Anti-SERT [8B6], Mouse IgG2a

MBS488912-5x02mg 5x0.2mg
EUR 2160

Mouse Anti-PTX Antibody, Mouse IgG2a

PTX-S343 100ug
EUR 2043.7
Description: Mouse Anti-PTX Antibody, Mouse IgG2a is recombinantly produced from human 293 cells (HEK293).

Anti-CD123 [7G3], Mouse IgG2a

MBS488955-02mg 0.2mg
EUR 520

Anti-CD123 [7G3], Mouse IgG2a

MBS488955-5x02mg 5x0.2mg
EUR 2160

Mouse anti Rat IgG2a (HRP)

43R-1581 100 ug
EUR 233
Description: Mouse anti Rat IgG2a antibody (HRP)

Rabbit anti Mouse IgG2a (rhodamine)

43R-IR011rd 1 mg
EUR 355
Description: Rabbit anti Mouse IgG2a secondary antibody (Rhodamine)

Rabbit anti Mouse IgG2a (rhodamine)

MBS539092-1mg 1mg
EUR 620

Rabbit anti Mouse IgG2a (rhodamine)

MBS539092-5x1mg 5x1mg
EUR 2635

Anti-Normal Mouse IgG2a Antibody

MBS4158477-01mg 0.1mg
EUR 1055

Anti-Normal Mouse IgG2a Antibody

MBS4158477-5x01mg 5x0.1mg
EUR 4485

Mouse Anti-Rat IgG2a-AP

MBS673744-1mL 1mL
EUR 420

Mouse Anti-Rat IgG2a-AP

MBS673744-5x1mL 5x1mL
EUR 1740

Mouse Anti-Rat IgG2a-PE

MBS673747-01mg 0.1mg
EUR 325

Mouse Anti-Rat IgG2a-PE

MBS673747-5x01mg 5x0.1mg
EUR 1315

Mouse Anti-Rat IgG2a-HRP

MBS673745-1mL 1mL
EUR 420

Mouse Anti-Rat IgG2a-HRP

MBS673745-5x1mL 5x1mL
EUR 1740

Mouse Anti-Rat IgG2a-CY5

MBS673748-01mg 0.1mg
EUR 430

Mouse Anti-Rat IgG2a-CY5

MBS673748-5x01mg 5x0.1mg
EUR 1795

Anti-VEGF [Bevacizumab], Mouse IgG2a

MBS488892-02mg 0.2mg
EUR 520

Anti-VEGF [Bevacizumab], Mouse IgG2a

MBS488892-5x02mg 5x0.2mg
EUR 2160

Mouse Anti-Rat IgG2a-UNLB

MBS673742-05mg 0.5mg
EUR 290

Mouse Anti-Rat IgG2a-UNLB

MBS673742-5x05mg 5x0.5mg
EUR 1155

Mouse Anti-Rat IgG2a-FITC

MBS673743-05mg 0.5mg
EUR 345

Mouse Anti-Rat IgG2a-FITC

MBS673743-5x05mg 5x0.5mg
EUR 1395

Mouse Anti-Rat IgG2a-BIOT

MBS673746-05mg 0.5mg
EUR 320

Mouse Anti-Rat IgG2a-BIOT

MBS673746-5x05mg 5x0.5mg
EUR 1295

Goat anti Mouse IgG2a (Alk Phos)

43R-IG062alk 1 ml
EUR 304
Description: Goat anti Mouse IgG2a secondary antibody (Alk Phos)

Goat anti Mouse IgG2a (Alk Phos)

MBS539198-05mg 0.5mg
EUR 565

Goat anti Mouse IgG2a (Alk Phos)

MBS539198-5x05mg 5x0.5mg
EUR 2385

Rat anti Mouse IgG2a Heavy Chain

10R-I115a 1 mg
EUR 535
Description: Rat anti Mouse IgG2a Heavy Chain antibody

Rabbit anti Mouse IgG2a (Alk Phos)

43C-CB5133 1 mg
EUR 428
Description: Rabbit anti Mouse IgG2a secondary antibody (Alk Phos)

RAT ANTI MOUSE IgG2a HEAVY CHAIN

MBS212237-1mg 1mg
EUR 755

RAT ANTI MOUSE IgG2a HEAVY CHAIN

MBS212237-5x1mg 5x1mg
EUR 3220

RAT ANTI MOUSE IgG2a HEAVY CHAIN

MBS235047-025mg 0.25mg
EUR 490

RAT ANTI MOUSE IgG2a HEAVY CHAIN

MBS235047-5x025mg 5x0.25mg
EUR 2025

Rat anti Mouse IgG2a Heavy Chain

MBS530830-1mg 1mg
EUR 910

Rat anti Mouse IgG2a Heavy Chain

MBS530830-5x1mg 5x1mg
EUR 3950

Rabbit anti Mouse IgG2a (Alk Phos)

MBS538768-1mg 1mg
EUR 745

Rabbit anti Mouse IgG2a (Alk Phos)

MBS538768-5x1mg 5x1mg
EUR 3210

Goat anti Mouse IgG2a Antibody (HRP)

20-abx239825
  • Ask for price
  • Ask for price
  • 100 ul
  • 500 ul

Rabbit anti Mouse IgG2a (Texas Red)

43C-CB5125 1 mg
EUR 355
Description: Rabbit anti Mouse IgG2a secondary antibody

RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP

MBS235030-05mg 0.5mg
EUR 695

RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP

MBS235030-5x05mg 5x0.5mg
EUR 2960

RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP

MBS211164-05mg 0.5mg
EUR 640

RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP

MBS211164-5x05mg 5x0.5mg
EUR 2710

Rabbit anti Mouse IgG2a (Texas Red)

MBS538763-1mg 1mg
EUR 620

Rabbit anti Mouse IgG2a (Texas Red)

MBS538763-5x1mg 5x1mg
EUR 2635

Anti-CD8 [G10-1], Mouse IgG2a

MBS488906-02mg 0.2mg
EUR 520

Anti-CD8 [G10-1], Mouse IgG2a

MBS488906-5x02mg 5x0.2mg
EUR 2160

RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC

MBS210741-05mg 0.5mg
EUR 640

RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC

MBS210741-5x05mg 5x0.5mg
EUR 2710

RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC

MBS235021-05mg 0.5mg
EUR 695

RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC

MBS235021-5x05mg 5x0.5mg
EUR 2960

Anti-NK1.1 [PK-136], Mouse IgG2a

MBS488969-02mg 0.2mg
EUR 520

Anti-NK1.1 [PK-136], Mouse IgG2a

MBS488969-5x02mg 5x0.2mg
EUR 2160

RAT ANTI MOUSE IgG2a HEAVY CHAIN:Biotin

MBS235009-05mg 0.5mg
EUR 695

RAT ANTI MOUSE IgG2a HEAVY CHAIN:Biotin

MBS235009-5x05mg 5x0.5mg
EUR 2960

Anti-CD18 [1B4], Mouse IgG2a, Kappa

MBS488524-02mg 0.2mg
EUR 520

Anti-CD18 [1B4], Mouse IgG2a, Kappa

MBS488524-5x02mg 5x0.2mg
EUR 2160

Mouse anti-OVA IgG2a (OVA IgG2a) quantitative detection ELISA Kit

MBS3809955-10x96StripWells 10x96-Strip-Wells
EUR 6545

Mouse anti-OVA IgG2a (OVA IgG2a) quantitative detection ELISA Kit

MBS3809955-5x96StripWells 5x96-Strip-Wells
EUR 3325

Mouse anti-OVA IgG2a (OVA IgG2a) quantitative detection ELISA Kit

MBS3809955-96StripWells 96-Strip-Wells
EUR 720

Goat anti Mouse IgG2a (subclass specific)

MBS571897-10mg 10mg
EUR 715

Goat anti Mouse IgG2a (subclass specific)

MBS571897-5x10mg 5x10mg
EUR 3080

Goat anti Mouse IgG2a (subclass specific)

MBS571903-1mL 1mL
EUR 365

Goat anti Mouse IgG2a (subclass specific)

MBS571903-5x1mL 5x1mL
EUR 1490

Goat Anti Mouse Igg2a Polyclonal Antibody

CPBT-68030GM 0.5 mg
EUR 696

Sheep anti Mouse IgG2a (subclass specific)

MBS571586-1mL 1mL
EUR 365

Sheep anti Mouse IgG2a (subclass specific)

MBS571586-5x1mL 5x1mL
EUR 1490

Anti-CD41 [7E3 (Abciximab)], Mouse IgG2a

MBS488880-02mg 0.2mg
EUR 520

Anti-CD41 [7E3 (Abciximab)], Mouse IgG2a

MBS488880-5x02mg 5x0.2mg
EUR 2160

Rabbit anti Mouse IgG2a (subclass specific)

MBS571569-1mL 1mL
EUR 365

Rabbit anti Mouse IgG2a (subclass specific)

MBS571569-5x1mL 5x1mL
EUR 1490

Mouse Anti-Rat IgG2a H Antibody

abx401351-100g 100 µg Ask for price

Mouse Anti-Rat IgG2a H Antibody

abx401351-500g 500 µg Ask for price

Mouse Anti-Rat IgG2a H Antibody

abx401351-50g 50 µg
EUR 450

MOUSE ANTI RAT IgG2a HEAVY CHAIN

MBS235044-025mg 0.25mg
EUR 490

MOUSE ANTI RAT IgG2a HEAVY CHAIN

MBS235044-5x025mg 5x0.25mg
EUR 2025

Monoclonal Anti-PBD Antibody, Mouse IgG2a

PBD-S397 1mg
EUR 381.5
Description: Pyrrole benzodiazepine dimers (pyrololobenzodiazepine, PBD) A novel class of antibody-drug conjugates (ADCs) that produce highly cytotoxic DNA cross-linking, Completely different cellular targets were utilized to inhibit aurisatin and maytansinoid tubulin and produce different patterns of DNA damage to other DNA-interacting warheads, such as calicheamicin. For example, Zynlonta is a human-derived CD19-targeting ADC that is coupled to a pyrrole benzodiazepine (PBD) dimer toxin. When PBD dimer enters a cell, it specifically binds to DNA, forming effective cytotoxic DNA crosslinking that stops cell division and kills cancer cells. Among them, CD19 is a specific antigen expressed on the surface of B cells and is the target of multiple CAR-T therapies.

MOUSE ANTI RAT IgG2a HEAVY CHAIN:HRP

MBS235027-05mg 0.5mg
EUR 1000

MOUSE ANTI RAT IgG2a HEAVY CHAIN:HRP

MBS235027-5x05mg 5x0.5mg
EUR 4315

Anti-CD20 [10F381 (rituximab)], Mouse IgG2a

MBS488874-02mg 0.2mg
EUR 520

Anti-CD20 [10F381 (rituximab)], Mouse IgG2a

MBS488874-5x02mg 5x0.2mg
EUR 2160

Anti-RSV [RSHZ19 (Felvizumab)], Mouse IgG2a

MBS488897-02mg 0.2mg
EUR 520

Anti-RSV [RSHZ19 (Felvizumab)], Mouse IgG2a

MBS488897-5x02mg 5x0.2mg
EUR 2160

MOUSE ANTI RAT IgG2a HEAVY CHAIN:FITC

MBS235018-05mg 0.5mg
EUR 640

MOUSE ANTI RAT IgG2a HEAVY CHAIN:FITC

MBS235018-5x05mg 5x0.5mg
EUR 2710

Mouse IgG2a Antibody

IgG-002 1000 µg
EUR 588
Description: This antibody is purified from culture supernatant of a hybridoma (mouse myeloma fused with spleen cells from a mouse, clone APR-C184) with protein A/G.

Mouse IgG2a Antibody

GWB-A874C9 0.25 mg Ask for price

Mouse IgG2a Antibody

GWB-E426C0 0.5 mg Ask for price

Mouse IgG2a Antibody

R20166-100UG 100ug
EUR 347.65
Description: This recombinant Mouse IgG2a antibody reacts to the Fc region of mIgG2a. No cross reactivity with mouse IgG1, IgG2b, IgG2c, IgG3, IgM, IgA, IgE, human/rat IgG.

Mouse IgG2a Antibody

R20166BTN-50UG 50ug
EUR 347.65
Description: This recombinant Mouse IgG2a antibody reacts to the Fc region of mouse IgG2a. No cross reactivity with mouse IgG1, IgG2b, IgG2c, IgG3, IgM, IgA, IgE, human IgG, or rat IgG.

Mouse IgG2a Antibody

R20166SAF-250UG 250ug
EUR 832.15
Description: This recombinant Mouse IgG2a antibody reacts to the Fc region of mIgG2a. No cross reactivity with mouse IgG1, IgG2b, IgG2c, IgG3, IgM, IgA, IgE, human/rat IgG.

GOAT ANTI MOUSE IGG2A, ANTISERA, 100 ML

7455540-100ML 1ML
EUR 156.4

GOAT ANTI MOUSE IGG2A, ANTISERA, 500 ML

7455540-500ML 1ML
EUR 684.94

Anti-CD40L [hu5c8 (Ruplizumab)], Mouse IgG2a

MBS488882-02mg 0.2mg
EUR 520

Anti-CD40L [hu5c8 (Ruplizumab)], Mouse IgG2a

MBS488882-5x02mg 5x0.2mg
EUR 2160

Mouse IgG2a

31C-CH1007 1 mg
EUR 373
Description: Purified Mouse IgG2a

Mouse IgG2a

C040308-10mg 10mg
EUR 2148

Mouse IgG2a

C040308-1mg 1mg
EUR 728.4

Mouse IgG2a

nAP-0002 1mg
EUR 459

Mouse IgG2a

MBS666889-01mg 0.1mg
EUR 725

Mouse IgG2a

MBS666889-5x01mg 5x0.1mg
EUR 3100

Mouse IgG2a

MBS666886-01mg 0.1mg
EUR 725

Mouse IgG2a

MBS666886-5x01mg 5x0.1mg
EUR 3100

Mouse IgG2a

MBS191388-1mg 1mg
EUR 335

Mouse IgG2a

MBS191388-5x1mg 5x1mg
EUR 1505

Mouse IgG2a

MBS537969-1mg 1mg
EUR 655

Mouse IgG2a

MBS537969-5x1mg 5x1mg
EUR 2805

GOAT ANTI MOUSE IGG2A, ANTISERA, 1 LTR

7455540-1LTR 1LTR
EUR 1274.98

Anti-CD11a [hu1124 (Efalizumab)], Mouse IgG2a

MBS488888-02mg 0.2mg
EUR 520

Anti-CD11a [hu1124 (Efalizumab)], Mouse IgG2a

MBS488888-5x02mg 5x0.2mg
EUR 2160

MOUSE ANTI RAT IgG2a HEAVY CHAIN:Biotin

MBS235006-05mg 0.5mg
EUR 640

MOUSE ANTI RAT IgG2a HEAVY CHAIN:Biotin

MBS235006-5x05mg 5x0.5mg
EUR 2710

Anti-IL-16 [14.1], Mouse IgG2a, Kappa

MBS488510-02mg 0.2mg
EUR 520

Anti-IL-16 [14.1], Mouse IgG2a, Kappa

MBS488510-5x02mg 5x0.2mg
EUR 2160

Anti-IL-5 [2E3], Mouse IgG2a, Kappa

MBS488517-02mg 0.2mg
EUR 520

Anti-IL-5 [2E3], Mouse IgG2a, Kappa

MBS488517-5x02mg 5x0.2mg
EUR 2160

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807057-01mg 0.1mg
EUR 490

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807057-5x01mg 5x0.1mg
EUR 1935

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807062-01mg 0.1mg
EUR 485

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807062-5x01mg 5x0.1mg
EUR 1925

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807066-01mg 0.1mg
EUR 480

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807066-5x01mg 5x0.1mg
EUR 1905

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807106-01mg 0.1mg
EUR 435

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807106-5x01mg 5x0.1mg
EUR 1700

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807127-01mg 0.1mg
EUR 480

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807127-5x01mg 5x0.1mg
EUR 1915

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807276-01mg 0.1mg
EUR 490

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807276-5x01mg 5x0.1mg
EUR 1940

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807282-01mg 0.1mg
EUR 475

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807282-5x01mg 5x0.1mg
EUR 1885

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807315-01mg 0.1mg
EUR 490

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807315-5x01mg 5x0.1mg
EUR 1945

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807316-01mg 0.1mg
EUR 485

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

MBS807316-5x01mg 5x0.1mg
EUR 1920

Mouse IgG2a (FITC) / Mouse IgG2a (PE) Isotype Control

abx405002-100g 100 µg
EUR 500

Rat anti Mouse IgG2a Heavy Chain (biotin)

61R-I115aBT 1 mg
EUR 623
Description: Rat anti Mouse IgG2a Heavy Chain antibody (biotin)

Rat anti Mouse IgG2a Heavy Chain (biotin)

MBS530926-1mg 1mg
EUR 1050

Rat anti Mouse IgG2a Heavy Chain (biotin)

MBS530926-5x1mg 5x1mg
EUR 4580

Mouse IgG2a (FITC) / Mouse IgG2a (RPE) Isotype Control

abx405002-50tests 50 tests
EUR 744

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS806986-01mg 0.1mg
EUR 490

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS806986-5x01mg 5x0.1mg
EUR 1940

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807024-01mg 0.1mg
EUR 490

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807024-5x01mg 5x0.1mg
EUR 1945

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807052-01mg 0.1mg
EUR 485

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807052-5x01mg 5x0.1mg
EUR 1925

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807124-01mg 0.1mg
EUR 480

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807124-5x01mg 5x0.1mg
EUR 1910

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807249-01mg 0.1mg
EUR 485

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807249-5x01mg 5x0.1mg
EUR 1930

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807301-01mg 0.1mg
EUR 490

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807301-5x01mg 5x0.1mg
EUR 1950

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807308-01mg 0.1mg
EUR 475

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807308-5x01mg 5x0.1mg
EUR 1890

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807332-01mg 0.1mg
EUR 485

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807332-5x01mg 5x0.1mg
EUR 1920

Mouse Anti-Human PP5 Monoclonal IgG2a

MBS807336-01mg 0.1mg
EUR 490

Anti-inflammatory glucocorticoid action: genomic insights and emerging concepts.

Glucocorticoids (GCs) are widely used immunomodulators. They regulate gene expression by binding and activating the Glucocorticoid Receptor (GR), but underlying transcriptional mechanisms remain enigmatic. This review summarizes recent findings identifyingspecific GR-bound DNA sequences whose configuration may affect transcriptional output.

Additional factors affecting GR’s anti-inflammatory actions, including different chromatin states such as DNAse hypersensitive regions and histone marks will be discussed, together with the relevant transcriptional co-regulators and promoter/enhancer features. Furthermore, the involvement of non-coding RNAs such as lncRNAs, miRNAs and eRNAs adds another level of regulation to the GR’s transcriptional activity. Characterizing and understanding these multiple mechanisms will be crucial for developing more targeted immunomodulatory therapies with reduced adverse effects such as obesity, diabetes and osteoporosis.