Computational genomic discovery of diverse gene clusters harbouring Fe-S flavoenzymes in anaerobic gut microbiota.

The gut contains an enormous diversity of simple as well as complex molecules from highly diverse food sources, together with host-secreted molecules. This presents a large metabolic opportunity for the gut microbiota, but little is known about how gut microbes are able to catabolize this large chemical diversity. Recently, Fe-S flavoenzymes were found to be key in the transformation of bile acids, catalysing the key step in the 7α-dehydroxylation pathway that allows gut bacteria to transform cholic acid into deoxycholic acid, an exclusively microbe-derived molecule with major implications for human health.

While this enzyme family has also been implicated in a limited number of other catalytic transformations, little is known about the extent to which it is of more global importance in gut microbial metabolism. Here, we perform a large-scale computational genomic analysis to show that this enzyme superfamily has undergone a remarkable expansion in Clostridiales, and occurs throughout a diverse array of >1000 different families of putative metabolic gene clusters. Analysis of the enzyme content of these gene clusters suggests that they encode pathways with a wide range of predicted substrate classes, including saccharides, amino acids/peptides and lipids.

Altogether, these results indicate a potentially important role of this protein superfamily in the human gut, and our dataset provides significant opportunities for the discovery of novel pathways that may have significant effects on human health.

Goat anti Mouse IgG2a

FNSA-0087 500 uL
EUR 367.92
Description: Goat anti Mouse IgG2a secondary antibody

Rabbit anti Mouse IgG2a

41C-CB5127 1 mg
EUR 302
Description: Rabbit anti Mouse IgG2a secondary antibody

Mouse anti Rat IgG2a

41R-1118 100 ug
EUR 218
Description: Mouse anti Rat IgG2a secondary antibody

Goat anti Mouse IgG2a (HRP)

43R-IG064hrp 1 ml
EUR 422
Description: Goat anti Mouse IgG2a secondary antibody (HRP)

Goat anti Mouse IgG2a (FITC)

43R-IG063ft 1 ml
EUR 369
Description: Goat anti Mouse IgG2a secondary antibody (FITC)

Rat anti Mouse IgG2a (biotin)

61R-I117bBT 1 mg
EUR 623
Description: Rat anti Mouse IgG2a antibody (biotin)

Rabbit anti Mouse IgG2a (FITC)

43C-CB5128 1 mg
EUR 351
Description: Rabbit anti Mouse IgG2a secondary antibody (FITC)

Rabbit anti Mouse IgG2a (biotin)

43C-CB5131 1 mg
EUR 355
Description: Rabbit anti Mouse IgG2a secondary antibody (biotin)

Mouse anti Rat IgG2a (HRP)

43R-1581 100 ug
EUR 233
Description: Mouse anti Rat IgG2a antibody (HRP)

Rabbit anti Mouse IgG2a (rhodamine)

43R-IR011rd 1 mg
EUR 355
Description: Rabbit anti Mouse IgG2a secondary antibody (Rhodamine)

Mouse Anti-PTX Antibody, Mouse IgG2a

PTX-S343 100ug
EUR 2043.7
Description: Mouse Anti-PTX Antibody, Mouse IgG2a is recombinantly produced from human 293 cells (HEK293).

Goat anti Mouse IgG2a (Alk Phos)

43R-IG062alk 1 ml
EUR 304
Description: Goat anti Mouse IgG2a secondary antibody (Alk Phos)

Rat anti Mouse IgG2a Heavy Chain

10R-I115a 1 mg
EUR 535
Description: Rat anti Mouse IgG2a Heavy Chain antibody

Rabbit anti Mouse IgG2a (Alk Phos)

43C-CB5133 1 mg
EUR 428
Description: Rabbit anti Mouse IgG2a secondary antibody (Alk Phos)

Goat anti Mouse IgG2a Antibody (HRP)

20-abx239825
  • Ask for price
  • Ask for price
  • 100 ul
  • 500 ul

Rabbit anti Mouse IgG2a (Texas Red)

43C-CB5125 1 mg
EUR 355
Description: Rabbit anti Mouse IgG2a secondary antibody

Goat Anti Mouse Igg2a Polyclonal Antibody

CPBT-68030GM 0.5 mg
EUR 696

Mouse IgG2a Antibody

IgG-002 1000 µg
EUR 588
Description: This antibody is purified from culture supernatant of a hybridoma (mouse myeloma fused with spleen cells from a mouse, clone APR-C184) with protein A/G.

Mouse IgG2a Antibody

GWB-A874C9 0.25 mg Ask for price

Mouse IgG2a Antibody

GWB-E426C0 0.5 mg Ask for price

Mouse IgG2a Antibody

R20166-100UG 100ug
EUR 347.65
Description: This recombinant Mouse IgG2a antibody reacts to the Fc region of mIgG2a. No cross reactivity with mouse IgG1, IgG2b, IgG2c, IgG3, IgM, IgA, IgE, human/rat IgG.

Mouse IgG2a Antibody

R20166BTN-50UG 50ug
EUR 347.65
Description: This recombinant Mouse IgG2a antibody reacts to the Fc region of mouse IgG2a. No cross reactivity with mouse IgG1, IgG2b, IgG2c, IgG3, IgM, IgA, IgE, human IgG, or rat IgG.

Mouse IgG2a Antibody

R20166SAF-250UG 250ug
EUR 832.15
Description: This recombinant Mouse IgG2a antibody reacts to the Fc region of mIgG2a. No cross reactivity with mouse IgG1, IgG2b, IgG2c, IgG3, IgM, IgA, IgE, human/rat IgG.

Mouse IgG2a

31C-CH1007 1 mg
EUR 373
Description: Purified Mouse IgG2a

Mouse IgG2a

C040308-10mg 10mg
EUR 2148

Mouse IgG2a

C040308-1mg 1mg
EUR 728.4

GOAT ANTI MOUSE IGG2A, ANTISERA, 100 ML

7455540-100ML 1ML
EUR 156.4

GOAT ANTI MOUSE IGG2A, ANTISERA, 500 ML

7455540-500ML 1ML
EUR 684.94

GOAT ANTI MOUSE IGG2A, ANTISERA, 1 LTR

7455540-1LTR 1LTR
EUR 1274.98

Rat anti Mouse IgG2a Heavy Chain (biotin)

61R-I115aBT 1 mg
EUR 623
Description: Rat anti Mouse IgG2a Heavy Chain antibody (biotin)

Mouse IgG2a (FITC) / Mouse IgG2a (RPE) Isotype Control

abx405002-50tests 50 tests
EUR 744

Goat Anti Mouse Igg2a Polyclonal Antibody,HRP

CPBT-68029GM 1 ml
EUR 696

Goat Anti Mouse Igg2a Polyclonal Antibody,RPE

CPBT-68031GM 0.1 mg
EUR 852

Goat Anti Mouse Igg2a Polyclonal Antibody,FITC

CPBT-68028GM 0.5 mg
EUR 696

Goat Anti Mouse Igg2a Polyclonal Antibody,FITC

CPBT-68041GM 0.4 mg
EUR 651.6

Mouse Anti M2A IgG2a Antibody ELISA kit

E01A17687 96T
EUR 700
Description: ELISA

Mouse Anti M2A IgG2a Antibody ELISA kit

E03A0470-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Anti M2A IgG2a Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti M2A IgG2a Antibody ELISA kit

E03A0470-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Anti M2A IgG2a Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti M2A IgG2a Antibody ELISA kit

E03A0470-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Anti M2A IgG2a Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-GST(Mouse IgG2a-κ), Monoclonal(GS019), AS

04435-26 200UG
EUR 315

Anti-GST(Mouse IgG2a-κ), Monoclonal(GS019), AS

04435-84 50UG
EUR 105

PE anti-mouse IgG2a

E16SKP501-025U 25 μg
EUR 281.67
Description: Available in various conjugation types.

PE anti-mouse IgG2a

E16SKP501-100U 100 μg
EUR 628.33
Description: Available in various conjugation types.

Rabbit Anti Mouse Igg2a Polyclonal Antibody,FITC

CPBT-68017RM 1 mg
EUR 1070.4

APC anti-mouse IgG2a

E16SKA501-025U 25 μg
EUR 303.33
Description: Available in various conjugation types.

APC anti-mouse IgG2a

E16SKA501-100U 100 μg
EUR 650
Description: Available in various conjugation types.

anti-mouse IgG2a mAb

E4A03B13 50ug
EUR 255
Description: Available in various conjugation types.

Mouse IgG2a K antibody

10R-I117a 500 ug
EUR 642
Description: Mouse Controls & Calibrators Mouse IgG2a K antibody

Mouse Anti-LPS IgG2a Antibody Assay Kit

6110 1 kit
EUR 377
Description: Serum, Plasma

Mouse Anti-SEB IgG2a Antibody Assay Kit

6216 1 kit
EUR 377
Description: Serum, Plasma

Mouse Anti-SEA IgG2a Antibody Assay Kit

6220 1 kit
EUR 377
Description: Serum, Plasma

Mouse Anti-OVA IgG2a Antibody Assay Kit

3015 1 kit
EUR 415
Description: Serum, Plasma

FITC anti-mouse IgG2a

E16SKF501-050U 50 μg
EUR 303.33
Description: Available in various conjugation types.

FITC anti-mouse IgG2a

E16SKF501-500U 500 μg
EUR 758.33
Description: Available in various conjugation types.

Mouse IgG2a Antibody (RPE)

GWB-2E0454 0.1 mg Ask for price

Mouse IgG2a Antibody (HRP)

GWB-77C804 1 ml Ask for price

Mouse anti-Rat IgG2a Heavy Chain Antibody

abx401351-025mg 0.25 mg
EUR 678

Mouse IgG2a Antibody (FITC)

GWB-211730 1 mg Ask for price

Mouse IgG2a Antibody (FITC)

GWB-E9C547 0.5 mg Ask for price

Monoclonal Anti-IFNγ Antibody, Mouse IgG2a (8C5F8)

IFN-S120 100ug
EUR 2140
Description: Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.

Anti-Mouse IgG2a antibody

STJ16100002 0.5 mL
EUR 326.4

Anti-Mouse IgG2a antibody

STJ16100631 1 mL
EUR 844.8

Anti-Mouse IgG2a antibody

STJ16100632 1 mL
EUR 1029.6

Anti-Mouse IgG2a antibody

STJ16100633 1 mL
EUR 1786.8

Anti-Mouse IgG2a antibody

STJ16100649 1 mL
EUR 844.8

Anti-Mouse IgG2a antibody

STJ16100650 1 mL
EUR 1786.8

Anti-Mouse IgG2a Antibody

83501 1mg
EUR 227

Biotin anti-mouse IgG2a

E16SKB501-050U 50 μg
EUR 303.33
Description: Available in various conjugation types.

Biotin anti-mouse IgG2a

E16SKB501-500U 500 μg
EUR 758.33
Description: Available in various conjugation types.

Goat Anti Mouse IgG2a Polyclonal Affinity Purified

IGTAMSIGG2AAP1MG each
EUR 308
Description: Goat Anti Mouse IgG2a Polyclonal Affinity Purified

Mouse Anti-Gliadin IgG2a Antibody Assay Kit

3053 1 kit
EUR 404
Description: Serum, Plasma

Mouse IgG2a (HRP)

65C-CH1009 100 µg
EUR 247
Description: Purified Mouse IgG2a HRP conjugate

Mouse IgG2a Antibody (Biotin)

GWB-99D54E 1 mg Ask for price

Purified anti-mouse IgG2a

E16SKU501-050U 50 μg
EUR 260
Description: Available in various conjugation types.

Purified anti-mouse IgG2a

E16SKU501-500U 500 μg
EUR 628.33
Description: Available in various conjugation types.

Mouse IgG2a (FITC)

65C-CH1008 100 µg
EUR 198
Description: Purified Mouse IgG2a FITC conjugate

GOAT ANTI MOUSE IGG2A, AFFINITY PURIFIED, 100 MG

7455547-100MG 1MG
EUR 1093.43

GOAT ANTI MOUSE IGG2A, AFFINITY PURIFIED, 10 MG

7455547-10MG 1MG
EUR 166.65

GOAT ANTI MOUSE IGG2A, AFFINITY PURIFIED, 1 G

7455547-1G 1G
EUR 4911.8

Anti-TIMP1 antibody *Mouse anti-human, monoclonal IgG2a*

V100070 50 ug
EUR 367.2

Anti-TIMP1 antibody *Mouse anti-human, monoclonal IgG2a*

V100071 1 mg
EUR 471.6

Mouse IgG2a kappa

GWB-741A84 1 mg Ask for price

Mouse IgG2A ELISA

KT-404 96 tests
EUR 400

Mouse IgG2a protein

31R-1083 1 mg
EUR 229
Description: Purified native Mouse IgG2a protein

Mouse IgG2a Protein

E40MOP1834 20ug
EUR 495

Mouse IgG2a Protein

E40MOP2040 20ug
EUR 495

Mouse IgG2a Control

ICIGG2AB-100 100 µg
EUR 239.4

Mouse IgG2a Control

ICIGG2ACFB-100 100 µg
EUR 387.6

Goat Anti Mouse Igg2a Polyclonal Antibody,Alk. Phos.

CPBT-68027GM 1 ml
EUR 696

Mouse Anti-E. coli IgG2a Antibody Assay Kit

6210 1 kit
EUR 377
Description: Serum, Plasma

Rat Anti Mouse Igg2a Heavy Chain Monoclonal Antibody

CABT-54681RM 1 mg
EUR 982.8

Rat Anti Mouse Igg2a Heavy Chain Monoclonal Antibody

CABT-54687RM 0.25 mg
EUR 651.6

Mouse Control IgG2a

mabg2a-ctrlm 100 µg
EUR 105

Mouse Control IgG2a

mabg2a-ctrlm-05 5 x 100 µg
EUR 163.8

Mouse anti-Rat IgG2a Heavy Chain Antibody (HRP)

abx401354-05mg 0.5 mg
EUR 1045.2

Mouse anti-Rat IgG2a Heavy Chain Antibody (FITC)

abx401353-05mg 0.5 mg
EUR 861.6

anti-mouse IgG2a mAb, AP

E409B13-AP100 100μL
EUR 150

anti-mouse IgG2a+b mAb

E4A03B15 50ug
EUR 255
Description: Available in various conjugation types.

Mouse IgG2a Antibody (Alk Phos)

GWB-FB5BB0 1 ml Ask for price

Anti-CD3 epsilon (Muromonab), Mouse IgG2a, kappa Antibody

A2008-200 200 µg
EUR 612

Mouse Anti-Rat IgG2a (2a chain specific), Antibody

GWB-4C12B5 0.1 mg Ask for price

Mouse Anti-Rat IgG2a (2a chain specific), Antibody

GWB-2519EB 0.5 mg Ask for price

Mouse Anti-Rat IgG2a (2a chain specific), Antibody

GWB-1A01FA 0.5 mg Ask for price

Mouse Anti-Rat IgG2a (2a chain specific), Antibody

GWB-F38061 0.1 mg Ask for price

Mouse Anti-Rat IgG2a (2a chain specific), Antibody

GWB-E09F6E 1 ml Ask for price

Mouse Anti-Rat IgG2a (2a chain specific), Antibody

GWB-D25B09 0.5 mg Ask for price

Mouse Anti-Rat IgG2a (2a chain specific), Antibody

GWB-DBDDD5 1 ml Ask for price

anti-mouse IgG2a mAb, HRP

E409B13-HRP100 100μL
EUR 150

Mouse IgG2a Antibody (Texas Red)

GWB-B61774 1 mg Ask for price

Mouse anti-Rat IgG2a Heavy Chain Antibody (Biotin)

abx401352-05mg 0.5 mg
EUR 861.6

PE-Cy7 anti-mouse IgG2a

E16SKN501-025U 25 μg
EUR 325
Description: Available in various conjugation types.

PE-Cy7 anti-mouse IgG2a

E16SKN501-100U 100 μg
EUR 715
Description: Available in various conjugation types.

HRP Goat Anti-Mouse IgG2a

AS065 100 ul
EUR 35.75

Rat Anti-Mouse IgG2a Antibody

abx023344-025mg 0.25 mg
EUR 844.8

Mouse IgG2a Heavy Chain Antibody

GWB-8586F4 1 mg Ask for price

Mouse IgG2a Heavy Chain Antibody

GWB-CA8FD2 0.25 mg Ask for price

Mouse IgG2a Rat mAb

E2230018 100ul
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Goat anti-Mouse IgG2a Antibody

abx401475-05mg 0.5 mg
EUR 444

PerCP-Cy5.5 anti-mouse IgG2a

E16SKQ501-025U 25 μg
EUR 325
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-mouse IgG2a

E16SKQ501-100U 100 μg
EUR 715
Description: Available in various conjugation types.

Mouse Monoclonal (3576) Anti-Yellow Fever Virus IgG2a

YFV11-M 100 ul
EUR 578.4

Mouse Monoclonal Anti-Mouse CD11a, PE (Clone 8-6.2) (mouse IgG2a)

MCD011A-PE 100 tests
EUR 562.8

Mouse Anti-HDM Der p2 IgG2a Antibody Assay Kit

3066 1 kit
EUR 417
Description: Allergy, Immunology

APC-Cy5.5 mouse IgG2a

E16FMCN002-100 100 tests
EUR 715
Description: Available in various conjugation types.

Mouse IgG2a ELISA Kit

E28L0656 96T
EUR 666.67

Mouse IgG2a ELISA Kit

E28L0656-48 48T
EUR 380.95

Mouse IgG2a ELISA Kit

E28L0656-96 96T
EUR 634.92

Mouse IgG2a ELISA Kit

GWB-CF2E7B 96 well Ask for price

Mouse IgG2a ELISA kit

F046 1 kit (96 wells plate)
EUR 1056
Description: Mouse IgG2a ELISA kit by Cygnus Technologies is available in Europe via Gentaur.

Mouse IgG2a ELISA Kit

IMSIGG2AKT each
EUR 475
Description: Mouse IgG2a ELISA Kit

Mouse IgG2a ELISA kit

RK04562 96T
EUR 280

Rat Anti Mouse Igg2a Heavy Chain Monoclonal Antibody,HRP

CABT-54680RM 0.5 mg
EUR 1306.8

Rat Anti Mouse Igg2a Heavy Chain Monoclonal Antibody,HRP

CABT-54686RM 0.5 mg
EUR 1070.4

Mouse Monoclonal Anti-Mouse CD72.1, PE (Clone CT-72.1) (mouse IgG2a)

MCD072-PE 100 tests
EUR 562.8

Mouse Anti-Ro60 IgG2a Monoclonal Antibody, Clone 1G4H5

7126 1 mg/ml x 0.1 ml
EUR 238
Description: Mouse Anti-Ro60 IgG2a Monoclonal Antibody

Mouse Anti-SEA IgG2a Monoclonal Antibody, Clone 2E11F7

7107 1 mg/ml x 0.1 ml
EUR 321
Description: Mouse Anti-SEA IgG2a Monoclonal Antibody

Mouse Anti-HDM IgG2a Monoclonal Antibody, Clone 2A11C4

7127 1 mg/ml x 0.1 ml
EUR 238
Description: Mouse Anti-HDM IgG2a Monoclonal Antibody

Rat Anti Mouse Igg2a Heavy Chain Monoclonal Antibody,FITC

CABT-54679RM 0.5 mg
EUR 1070.4

Rat Anti Mouse Igg2a Heavy Chain Monoclonal Antibody,FITC

CABT-54685RM 0.5 mg
EUR 889.2

Mouse Monoclonal Anti-Mouse CD11a, FITC (Clone 8-6.2) (mouse IgG2a)

MCD011A-F 100 tests
EUR 562.8

Mouse IgG2a goat polyclonal antibody

AP05385AP-N 1 ml Ask for price

OAIA00394-1MG - Mouse IgG2A Antibody

OAIA00394-1MG 1.0mg
EUR 199

OASB02713-1MG - Mouse IgG2a Antibody

OASB02713-1MG 1.0mg
EUR 209

OASB02718-1MG - Mouse IgG2a Antibody

OASB02718-1MG 1.0mg
EUR 259

OASB00027-1MG - Mouse IgG2a Antibody

OASB00027-1MG 1.0mg
EUR 369

Mouse Anti-Mouse CTLA4 IgG2a Monoclonal Antibody, Clone 2H9G9

7133 2 mg/ml x 5.0 ml
EUR 524

Mouse Monoclonal Anti-Mouse CD72.1, FITC (Clone CT-72.1) (mouse IgG2a)

MCD072-F 100 tests
EUR 562.8

Anti-GST(Mouse IgG2a-κ), Monoclonal(GS019), AS, POD Conjugate

04559-74 50UG
EUR 126

Rat IgG2a Mouse mAb

E2230026 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rat Anti Mouse Igg2a Heavy Chain Monoclonal Antibody,Biotin

CABT-54684RM 0.5 mg
EUR 889.2

Mouse Anti-Mouse CTLA4 IgG2a Monoclonal Antibody, Clone 4E12D1

7131 1 mg/ml x 0.1 ml
EUR 238
Description: Mouse Anti-Mouse CTLA4 IgG2a Monoclonal Antibody

Anti-Myeloperoxidase (MPO) antibody *Mouse anti-human, monoclonal IgG2a*

V100100 50 ug
EUR 367.2

Anti-Myeloperoxidase (MPO) antibody *Mouse anti-human, monoclonal IgG2a*

V100101 1 mg
EUR 889.2

Mouse IgG2a Isotype Control Antibody:Biotin (HOPC-1) Mouse IgG2a Isotype Control Antibody:Biotin (HOPC-1)

MAB12223-100 0.1
EUR 196.47
Description: Mouse monoclonal antibody, IgG2a isotype control, conjugated to Biotin

Mouse Monoclonal Anti-Mouse CD11a, Biotin (Clone 8-6.2) (mouse IgG2a)

MCD011A-B 100 tests
EUR 562.8

Mouse Anti-Gliadin IgG2a Monoclonal Antibody, Clone 1H1D9

7148 1 mg/ml x 0.1 ml
EUR 238

OASB02244-500UG - Mouse IgG2a Antibody

OASB02244-500UG 0.5mg
EUR 229

Mouse Monoclonal Anti-Mouse CD72.1, Biotin (Clone CT-72.1) (mouse IgG2a)

MCD072-B 100 tests
EUR 562.8

Anti-Influenza B Virus Mouse IgG2a Self-pair Antibody

A2084-100 100 µg
EUR 381.6

Mouse IgG2a, kappa Protein

abx061466-1mg 1 mg
EUR 861.6

Mouse Monoclonal Anti-Mouse CD11a, Purified (Clone 8-6.2) (mouse IgG2a)

MCD011A-M 100 ug
EUR 578.4

Recombinant Mouse IgG2A Fc

FC04-10ug 10ug
EUR 96
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Mouse IgG2A Fc

FC04-1mg 1mg
EUR 850.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Mouse IgG2A Fc

FC04-500ug 500ug
EUR 613.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Mouse IgG2A Fc

FC04-50ug 50ug
EUR 169.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Mouse Monoclonal Anti-Mouse CD72.1, Purified (Clone CT-72.1) (mouse IgG2a)

MCD072-M 100 ug
EUR 578.4

Mouse Monoclonal Anti-Rat CD2 PE (Clone OX-34) (mouse IgG2a)

RCD002-PE 100 tests
EUR 562.8

Mouse Monoclonal Anti-Rat CD11a PE (Clone WT.1) (mouse IgG2a)

RCD011A-PE 100 tests
EUR 562.8

Mouse IgG2a Isotype Control

abx139004-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control

abx139005-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control

abx139009-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control

10R-I117d 1 mg
EUR 484
Description: Purified Mouse IgG2a Isotype Control

Mouse IgG2a Isotype Control

abx200572-100ug 100 ug
EUR 376.8

Mouse IgG2a Isotype Control

abx405013-100tests 100 tests
EUR 493.2

Mouse IgG2a Isotype Control

abx405015-05mg 0.5 mg
EUR 828

Mouse IgG2a Isotype Control

abx405018-1mg 1 mg
EUR 1328.4

Mouse IgG2a Isotype Control

abx405070-100tests 100 tests
EUR 493.2

Mouse IgG2a Isotype Control

abx405073-05mg 0.5 mg
EUR 994.8

Mouse IgG2a Isotype Control

E2790004 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control

GWB-21CA6B 100 TESTS Ask for price

Mouse IgG2a Isotype Control

GWB-233A6A 100 TESTS Ask for price

Mouse IgG2a Isotype Control

GWB-260585 100 TESTS Ask for price

Mouse IgG2a Isotype Control

GWB-148AA9 0.5 mg Ask for price

Mouse IgG2a Isotype Control

GWB-1C9451 100 TESTS Ask for price

Mouse IgG2a Isotype Control

ICIGG2AA-50 50 µg
EUR 231

Anti-inflammatory glucocorticoid action: genomic insights and emerging concepts.

Glucocorticoids (GCs) are widely used immunomodulators. They regulate gene expression by binding and activating the Glucocorticoid Receptor (GR), but underlying transcriptional mechanisms remain enigmatic. This review summarizes recent findings identifyingspecific GR-bound DNA sequences whose configuration may affect transcriptional output.

Additional factors affecting GR’s anti-inflammatory actions, including different chromatin states such as DNAse hypersensitive regions and histone marks will be discussed, together with the relevant transcriptional co-regulators and promoter/enhancer features. Furthermore, the involvement of non-coding RNAs such as lncRNAs, miRNAs and eRNAs adds another level of regulation to the GR’s transcriptional activity. Characterizing and understanding these multiple mechanisms will be crucial for developing more targeted immunomodulatory therapies with reduced adverse effects such as obesity, diabetes and osteoporosis.