Computational genomic discovery of diverse gene clusters harbouring Fe-S flavoenzymes in anaerobic gut microbiota.

The gut contains an enormous diversity of simple as well as complex molecules from highly diverse food sources, together with host-secreted molecules. This presents a large metabolic opportunity for the gut microbiota, but little is known about how gut microbes are able to catabolize this large chemical diversity. Recently, Fe-S flavoenzymes were found to be key in the transformation of bile acids, catalysing the key step in the 7α-dehydroxylation pathway that allows gut bacteria to transform cholic acid into deoxycholic acid, an exclusively microbe-derived molecule with major implications for human health.

While this enzyme family has also been implicated in a limited number of other catalytic transformations, little is known about the extent to which it is of more global importance in gut microbial metabolism. Here, we perform a large-scale computational genomic analysis to show that this enzyme superfamily has undergone a remarkable expansion in Clostridiales, and occurs throughout a diverse array of >1000 different families of putative metabolic gene clusters. Analysis of the enzyme content of these gene clusters suggests that they encode pathways with a wide range of predicted substrate classes, including saccharides, amino acids/peptides and lipids.

Altogether, these results indicate a potentially important role of this protein superfamily in the human gut, and our dataset provides significant opportunities for the discovery of novel pathways that may have significant effects on human health.

Rat anti Mouse IgG2a
MBS531265-5x1mg	MyBiosource	5x1mg	EUR 3950

Goat anti Mouse IgG2a
41R-1128	Fitzgerald	1 mg	EUR 331
Description: Goat anti Mouse IgG2a secondary antibody

Goat anti Mouse IgG2a
FNSA-0087	FN Test	500 uL	EUR 367.92
Description: Goat anti Mouse IgG2a secondary antibody

GOAT ANTI MOUSE IgG2a
MBS235408-05mg	MyBiosource	0.5mg	EUR 265

GOAT ANTI MOUSE IgG2a
MBS235408-5x05mg	MyBiosource	5x0.5mg	EUR 1020

Rabbit anti Mouse IgG2a
41C-CB5127	Fitzgerald	1 mg	EUR 302
Description: Rabbit anti Mouse IgG2a secondary antibody

Rabbit anti Mouse IgG2a
MBS539829-1mg	MyBiosource	1mg	EUR 540

Rabbit anti Mouse IgG2a
MBS539829-5x1mg	MyBiosource	5x1mg	EUR 2280

Mouse anti Rat IgG2a
41R-1118	Fitzgerald	100 ug	EUR 218
Description: Mouse anti Rat IgG2a secondary antibody

Goat anti Mouse IgG2a (HRP)
43R-IG064hrp	Fitzgerald	1 ml	EUR 422
Description: Goat anti Mouse IgG2a secondary antibody (HRP)

Goat anti Mouse IgG2a (HRP)
MBS539084-1mg	MyBiosource	1mg	EUR 675

Goat anti Mouse IgG2a (HRP)
MBS539084-5x1mg	MyBiosource	5x1mg	EUR 2880

Goat anti Mouse IgG2a (FITC)
43R-IG063ft	Fitzgerald	1 ml	EUR 369
Description: Goat anti Mouse IgG2a secondary antibody (FITC)

Goat anti Mouse IgG2a (FITC)
MBS539072-1mg	MyBiosource	1mg	EUR 645

Goat anti Mouse IgG2a (FITC)
MBS539072-5x1mg	MyBiosource	5x1mg	EUR 2755

Rat anti Mouse IgG2a (biotin)
61R-I117bBT	Fitzgerald	1 mg	EUR 623
Description: Rat anti Mouse IgG2a antibody (biotin)

Rat anti Mouse IgG2a (biotin)
MBS530088-1mg	MyBiosource	1mg	EUR 1050

Rat anti Mouse IgG2a (biotin)
MBS530088-5x1mg	MyBiosource	5x1mg	EUR 4580

Rabbit anti Mouse IgG2a (FITC)
43C-CB5128	Fitzgerald	1 mg	EUR 351
Description: Rabbit anti Mouse IgG2a secondary antibody (FITC)

Rabbit anti Mouse IgG2a (FITC)
MBS539790-1mg	MyBiosource	1mg	EUR 620

Rabbit anti Mouse IgG2a (FITC)
MBS539790-5x1mg	MyBiosource	5x1mg	EUR 2635

Anti-HA [8H5], Mouse IgG2a
MBS488948-02mg	MyBiosource	0.2mg	EUR 520

Anti-HA [8H5], Mouse IgG2a
MBS488948-5x02mg	MyBiosource	5x0.2mg	EUR 2160

Rabbit anti Mouse IgG2a (biotin)
43C-CB5131	Fitzgerald	1 mg	EUR 355
Description: Rabbit anti Mouse IgG2a secondary antibody (biotin)

Rabbit anti Mouse IgG2a (biotin)
MBS538766-1mg	MyBiosource	1mg	EUR 620

Rabbit anti Mouse IgG2a (biotin)
MBS538766-5x1mg	MyBiosource	5x1mg	EUR 2635

Anti-SERT [8B6], Mouse IgG2a
MBS488912-02mg	MyBiosource	0.2mg	EUR 520

Anti-SERT [8B6], Mouse IgG2a
MBS488912-5x02mg	MyBiosource	5x0.2mg	EUR 2160

Anti-CD123 [7G3], Mouse IgG2a
MBS488955-02mg	MyBiosource	0.2mg	EUR 520

Anti-CD123 [7G3], Mouse IgG2a
MBS488955-5x02mg	MyBiosource	5x0.2mg	EUR 2160

Mouse anti Rat IgG2a (HRP)
43R-1581	Fitzgerald	100 ug	EUR 233
Description: Mouse anti Rat IgG2a antibody (HRP)

Rabbit anti Mouse IgG2a (rhodamine)
43R-IR011rd	Fitzgerald	1 mg	EUR 355
Description: Rabbit anti Mouse IgG2a secondary antibody (Rhodamine)

Rabbit anti Mouse IgG2a (rhodamine)
MBS539092-1mg	MyBiosource	1mg	EUR 620

Rabbit anti Mouse IgG2a (rhodamine)
MBS539092-5x1mg	MyBiosource	5x1mg	EUR 2635

Anti-Normal Mouse IgG2a Antibody
MBS4158477-01mg	MyBiosource	0.1mg	EUR 1055

Anti-Normal Mouse IgG2a Antibody
MBS4158477-5x01mg	MyBiosource	5x0.1mg	EUR 4485

Mouse Anti-Rat IgG2a-AP
MBS673744-1mL	MyBiosource	1mL	EUR 420

Mouse Anti-Rat IgG2a-AP
MBS673744-5x1mL	MyBiosource	5x1mL	EUR 1740

Mouse Anti-Rat IgG2a-PE
MBS673747-01mg	MyBiosource	0.1mg	EUR 325

Mouse Anti-Rat IgG2a-PE
MBS673747-5x01mg	MyBiosource	5x0.1mg	EUR 1315

Mouse Anti-Rat IgG2a-HRP
MBS673745-1mL	MyBiosource	1mL	EUR 420

Mouse Anti-Rat IgG2a-HRP
MBS673745-5x1mL	MyBiosource	5x1mL	EUR 1740

Mouse Anti-Rat IgG2a-CY5
MBS673748-01mg	MyBiosource	0.1mg	EUR 430

Mouse Anti-Rat IgG2a-CY5
MBS673748-5x01mg	MyBiosource	5x0.1mg	EUR 1795

Mouse Anti-Rat IgG2a-UNLB
MBS673742-05mg	MyBiosource	0.5mg	EUR 290

Mouse Anti-Rat IgG2a-UNLB
MBS673742-5x05mg	MyBiosource	5x0.5mg	EUR 1155

Mouse Anti-Rat IgG2a-FITC
MBS673743-05mg	MyBiosource	0.5mg	EUR 345

Mouse Anti-Rat IgG2a-FITC
MBS673743-5x05mg	MyBiosource	5x0.5mg	EUR 1395

Mouse Anti-Rat IgG2a-BIOT
MBS673746-05mg	MyBiosource	0.5mg	EUR 320

Mouse Anti-Rat IgG2a-BIOT
MBS673746-5x05mg	MyBiosource	5x0.5mg	EUR 1295

Anti-VEGF [Bevacizumab], Mouse IgG2a
MBS488892-02mg	MyBiosource	0.2mg	EUR 520

Anti-VEGF [Bevacizumab], Mouse IgG2a
MBS488892-5x02mg	MyBiosource	5x0.2mg	EUR 2160

Goat anti Mouse IgG2a (Alk Phos)
43R-IG062alk	Fitzgerald	1 ml	EUR 304
Description: Goat anti Mouse IgG2a secondary antibody (Alk Phos)

Goat anti Mouse IgG2a (Alk Phos)
MBS539198-05mg	MyBiosource	0.5mg	EUR 565

Goat anti Mouse IgG2a (Alk Phos)
MBS539198-5x05mg	MyBiosource	5x0.5mg	EUR 2385

Rat anti Mouse IgG2a Heavy Chain
10R-I115a	Fitzgerald	1 mg	EUR 535
Description: Rat anti Mouse IgG2a Heavy Chain antibody

Rabbit anti Mouse IgG2a (Alk Phos)
43C-CB5133	Fitzgerald	1 mg	EUR 428
Description: Rabbit anti Mouse IgG2a secondary antibody (Alk Phos)

RAT ANTI MOUSE IgG2a HEAVY CHAIN
MBS235047-025mg	MyBiosource	0.25mg	EUR 490

RAT ANTI MOUSE IgG2a HEAVY CHAIN
MBS235047-5x025mg	MyBiosource	5x0.25mg	EUR 2025

RAT ANTI MOUSE IgG2a HEAVY CHAIN
MBS212237-1mg	MyBiosource	1mg	EUR 755

RAT ANTI MOUSE IgG2a HEAVY CHAIN
MBS212237-5x1mg	MyBiosource	5x1mg	EUR 3220

Rat anti Mouse IgG2a Heavy Chain
MBS530830-1mg	MyBiosource	1mg	EUR 910

Rat anti Mouse IgG2a Heavy Chain
MBS530830-5x1mg	MyBiosource	5x1mg	EUR 3950

Rabbit anti Mouse IgG2a (Alk Phos)
MBS538768-1mg	MyBiosource	1mg	EUR 745

Rabbit anti Mouse IgG2a (Alk Phos)
MBS538768-5x1mg	MyBiosource	5x1mg	EUR 3210

Goat anti Mouse IgG2a Antibody (HRP)
20-abx239825	Abbexa	Ask for price Ask for price	100 ul 500 ul

Rabbit anti Mouse IgG2a (Texas Red)
43C-CB5125	Fitzgerald	1 mg	EUR 355
Description: Rabbit anti Mouse IgG2a secondary antibody

RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP
MBS235030-05mg	MyBiosource	0.5mg	EUR 695

RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP
MBS235030-5x05mg	MyBiosource	5x0.5mg	EUR 2960

RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP
MBS211164-05mg	MyBiosource	0.5mg	EUR 640

RAT ANTI MOUSE IgG2a HEAVY CHAIN:HRP
MBS211164-5x05mg	MyBiosource	5x0.5mg	EUR 2710

Rabbit anti Mouse IgG2a (Texas Red)
MBS538763-1mg	MyBiosource	1mg	EUR 620

Rabbit anti Mouse IgG2a (Texas Red)
MBS538763-5x1mg	MyBiosource	5x1mg	EUR 2635

Anti-CD8 [G10-1], Mouse IgG2a
MBS488906-02mg	MyBiosource	0.2mg	EUR 520

Anti-CD8 [G10-1], Mouse IgG2a
MBS488906-5x02mg	MyBiosource	5x0.2mg	EUR 2160

RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC
MBS235021-05mg	MyBiosource	0.5mg	EUR 695

RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC
MBS235021-5x05mg	MyBiosource	5x0.5mg	EUR 2960

RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC
MBS210741-05mg	MyBiosource	0.5mg	EUR 640

RAT ANTI MOUSE IgG2a HEAVY CHAIN:FITC
MBS210741-5x05mg	MyBiosource	5x0.5mg	EUR 2710

Anti-NK1.1 [PK-136], Mouse IgG2a
MBS488969-02mg	MyBiosource	0.2mg	EUR 520

Anti-NK1.1 [PK-136], Mouse IgG2a
MBS488969-5x02mg	MyBiosource	5x0.2mg	EUR 2160

RAT ANTI MOUSE IgG2a HEAVY CHAIN:Biotin
MBS235009-05mg	MyBiosource	0.5mg	EUR 695

RAT ANTI MOUSE IgG2a HEAVY CHAIN:Biotin
MBS235009-5x05mg	MyBiosource	5x0.5mg	EUR 2960

Anti-CD18 [1B4], Mouse IgG2a, Kappa
MBS488524-02mg	MyBiosource	0.2mg	EUR 520

Anti-CD18 [1B4], Mouse IgG2a, Kappa
MBS488524-5x02mg	MyBiosource	5x0.2mg	EUR 2160

Mouse anti-OVA IgG2a (OVA IgG2a) quantitative detection ELISA Kit
MBS3809955-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6545

Mouse anti-OVA IgG2a (OVA IgG2a) quantitative detection ELISA Kit
MBS3809955-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3325

Mouse anti-OVA IgG2a (OVA IgG2a) quantitative detection ELISA Kit
MBS3809955-96StripWells	MyBiosource	96-Strip-Wells	EUR 720

Goat anti Mouse IgG2a (subclass specific)
MBS571897-10mg	MyBiosource	10mg	EUR 715

Goat anti Mouse IgG2a (subclass specific)
MBS571897-5x10mg	MyBiosource	5x10mg	EUR 3080

Goat anti Mouse IgG2a (subclass specific)
MBS571903-1mL	MyBiosource	1mL	EUR 365

Goat anti Mouse IgG2a (subclass specific)
MBS571903-5x1mL	MyBiosource	5x1mL	EUR 1490

Goat Anti Mouse Igg2a Polyclonal Antibody
CPBT-68030GM	Creative Diagnostics	0.5 mg	EUR 540.54
Description: Goat

Sheep anti Mouse IgG2a (subclass specific)
MBS571586-1mL	MyBiosource	1mL	EUR 365

Sheep anti Mouse IgG2a (subclass specific)
MBS571586-5x1mL	MyBiosource	5x1mL	EUR 1490

Anti-CD41 [7E3 (Abciximab)], Mouse IgG2a
MBS488880-02mg	MyBiosource	0.2mg	EUR 520

Anti-CD41 [7E3 (Abciximab)], Mouse IgG2a
MBS488880-5x02mg	MyBiosource	5x0.2mg	EUR 2160

Mouse Anti-Rat IgG2a H Antibody
abx401351-100g	Abbexa	100 µg	Ask for price

Mouse Anti-Rat IgG2a H Antibody
abx401351-500g	Abbexa	500 µg	Ask for price

Mouse Anti-Rat IgG2a H Antibody
abx401351-50g	Abbexa	50 µg	EUR 450

Rabbit anti Mouse IgG2a (subclass specific)
MBS571569-1mL	MyBiosource	1mL	EUR 365

Rabbit anti Mouse IgG2a (subclass specific)
MBS571569-5x1mL	MyBiosource	5x1mL	EUR 1490

MOUSE ANTI RAT IgG2a HEAVY CHAIN
MBS235044-025mg	MyBiosource	0.25mg	EUR 490

MOUSE ANTI RAT IgG2a HEAVY CHAIN
MBS235044-5x025mg	MyBiosource	5x0.25mg	EUR 2025

Monoclonal Anti-PBD Antibody, Mouse IgG2a
PBD-S397	ACROBIOSYSTEMS	1mg	EUR 381.5
Description: Pyrrole benzodiazepine dimers (pyrololobenzodiazepine, PBD) A novel class of antibody-drug conjugates (ADCs) that produce highly cytotoxic DNA cross-linking, Completely different cellular targets were utilized to inhibit aurisatin and maytansinoid tubulin and produce different patterns of DNA damage to other DNA-interacting warheads, such as calicheamicin. For example, Zynlonta is a human-derived CD19-targeting ADC that is coupled to a pyrrole benzodiazepine (PBD) dimer toxin. When PBD dimer enters a cell, it specifically binds to DNA, forming effective cytotoxic DNA crosslinking that stops cell division and kills cancer cells. Among them, CD19 is a specific antigen expressed on the surface of B cells and is the target of multiple CAR-T therapies.

MOUSE ANTI RAT IgG2a HEAVY CHAIN:HRP
MBS235027-05mg	MyBiosource	0.5mg	EUR 1000

MOUSE ANTI RAT IgG2a HEAVY CHAIN:HRP
MBS235027-5x05mg	MyBiosource	5x0.5mg	EUR 4315

Mouse IgG2a
31C-CH1007	Fitzgerald	1 mg	EUR 373
Description: Purified Mouse IgG2a

Mouse IgG2a
CE40308-10mg	Unibiotest	10 mg	EUR 2000

Mouse IgG2a
CE40308-1mg	Unibiotest	1 mg	EUR 600

Mouse IgG2a
C040308-10mg	Unibiotest	10mg	EUR 2148

Mouse IgG2a
C040308-1mg	Unibiotest	1mg	EUR 728.4

Mouse IgG2a
MBS191388-1mg	MyBiosource	1mg	EUR 335

Mouse IgG2a
MBS191388-5x1mg	MyBiosource	5x1mg	EUR 1505

Mouse IgG2a
MBS537969-1mg	MyBiosource	1mg	EUR 655

Mouse IgG2a
MBS537969-5x1mg	MyBiosource	5x1mg	EUR 2805

Mouse IgG2a
MBS666886-01mg	MyBiosource	0.1mg	EUR 725

Mouse IgG2a
MBS666886-5x01mg	MyBiosource	5x0.1mg	EUR 3100

Mouse IgG2a
MBS666889-01mg	MyBiosource	0.1mg	EUR 725

Mouse IgG2a
MBS666889-5x01mg	MyBiosource	5x0.1mg	EUR 3100

Mouse IgG2a
nAP-0002	Angio Proteomie	1mg	EUR 459

Anti-CD20 [10F381 (rituximab)], Mouse IgG2a
MBS488874-02mg	MyBiosource	0.2mg	EUR 520

Anti-CD20 [10F381 (rituximab)], Mouse IgG2a
MBS488874-5x02mg	MyBiosource	5x0.2mg	EUR 2160

Anti-RSV [RSHZ19 (Felvizumab)], Mouse IgG2a
MBS488897-02mg	MyBiosource	0.2mg	EUR 520

Anti-RSV [RSHZ19 (Felvizumab)], Mouse IgG2a
MBS488897-5x02mg	MyBiosource	5x0.2mg	EUR 2160

Mouse IgG2a Antibody
GWB-A874C9	GenWay Biotech	0.25 mg	Ask for price

Mouse IgG2a Antibody
GWB-E426C0	GenWay Biotech	0.5 mg	Ask for price

Mouse IgG2a Antibody
IgG-002	ReliaTech	1000 µg	EUR 588
Description: This antibody is purified from culture supernatant of a hybridoma (mouse myeloma fused with spleen cells from a mouse, clone APR-C184) with protein A/G.

Mouse IgG2a Antibody
R20166SAF-250UG	NSJ Bioreagents	250ug	EUR 832.15
Description: This recombinant Mouse IgG2a antibody reacts to the Fc region of mIgG2a. No cross reactivity with mouse IgG1, IgG2b, IgG2c, IgG3, IgM, IgA, IgE, human/rat IgG.

MOUSE ANTI RAT IgG2a HEAVY CHAIN:FITC
MBS235018-05mg	MyBiosource	0.5mg	EUR 640

MOUSE ANTI RAT IgG2a HEAVY CHAIN:FITC
MBS235018-5x05mg	MyBiosource	5x0.5mg	EUR 2710

GOAT ANTI MOUSE IGG2A, ANTISERA, 100 ML
7455540-100ML	Lampire Biologicals Laboratories	1ML	EUR 156.4

GOAT ANTI MOUSE IGG2A, ANTISERA, 500 ML
7455540-500ML	Lampire Biologicals Laboratories	1ML	EUR 684.94

Anti-CD40L [hu5c8 (Ruplizumab)], Mouse IgG2a
MBS488882-02mg	MyBiosource	0.2mg	EUR 520

Anti-CD40L [hu5c8 (Ruplizumab)], Mouse IgG2a
MBS488882-5x02mg	MyBiosource	5x0.2mg	EUR 2160

GOAT ANTI MOUSE IGG2A, ANTISERA, 1 LTR
7455540-1LTR	Lampire Biologicals Laboratories	1LTR	EUR 1274.98

Anti-CD11a [hu1124 (Efalizumab)], Mouse IgG2a
MBS488888-02mg	MyBiosource	0.2mg	EUR 520

Anti-CD11a [hu1124 (Efalizumab)], Mouse IgG2a
MBS488888-5x02mg	MyBiosource	5x0.2mg	EUR 2160

MOUSE ANTI RAT IgG2a HEAVY CHAIN:Biotin
MBS235006-05mg	MyBiosource	0.5mg	EUR 640

MOUSE ANTI RAT IgG2a HEAVY CHAIN:Biotin
MBS235006-5x05mg	MyBiosource	5x0.5mg	EUR 2710

Mouse IgG2a (FITC) / Mouse IgG2a (PE) Isotype Control
abx405002-100g	Abbexa	100 µg	EUR 500

Mouse IgG2a (FITC) / Mouse IgG2a (RPE) Isotype Control
abx405002-50tests	Abbexa	50 tests	EUR 744

Anti-IL-16 [14.1], Mouse IgG2a, Kappa
MBS488510-02mg	MyBiosource	0.2mg	EUR 520

Anti-IL-16 [14.1], Mouse IgG2a, Kappa
MBS488510-5x02mg	MyBiosource	5x0.2mg	EUR 2160

Anti-IL-5 [2E3], Mouse IgG2a, Kappa
MBS488517-02mg	MyBiosource	0.2mg	EUR 520

Anti-IL-5 [2E3], Mouse IgG2a, Kappa
MBS488517-5x02mg	MyBiosource	5x0.2mg	EUR 2160

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807057-01mg	MyBiosource	0.1mg	EUR 490

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807057-5x01mg	MyBiosource	5x0.1mg	EUR 1935

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807062-01mg	MyBiosource	0.1mg	EUR 485

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807062-5x01mg	MyBiosource	5x0.1mg	EUR 1925

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807066-01mg	MyBiosource	0.1mg	EUR 480

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807066-5x01mg	MyBiosource	5x0.1mg	EUR 1905

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807106-01mg	MyBiosource	0.1mg	EUR 435

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807106-5x01mg	MyBiosource	5x0.1mg	EUR 1700

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807127-01mg	MyBiosource	0.1mg	EUR 480

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807127-5x01mg	MyBiosource	5x0.1mg	EUR 1915

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807276-01mg	MyBiosource	0.1mg	EUR 490

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807276-5x01mg	MyBiosource	5x0.1mg	EUR 1940

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807282-01mg	MyBiosource	0.1mg	EUR 475

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807282-5x01mg	MyBiosource	5x0.1mg	EUR 1885

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807315-01mg	MyBiosource	0.1mg	EUR 490

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807315-5x01mg	MyBiosource	5x0.1mg	EUR 1945

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807316-01mg	MyBiosource	0.1mg	EUR 485

Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
MBS807316-5x01mg	MyBiosource	5x0.1mg	EUR 1920

Rat anti Mouse IgG2a Heavy Chain (biotin)
61R-I115aBT	Fitzgerald	1 mg	EUR 623
Description: Rat anti Mouse IgG2a Heavy Chain antibody (biotin)

Rat anti Mouse IgG2a Heavy Chain (biotin)
MBS530926-1mg	MyBiosource	1mg	EUR 1050

Rat anti Mouse IgG2a Heavy Chain (biotin)
MBS530926-5x1mg	MyBiosource	5x1mg	EUR 4580

IgG2a, Mouse
MBS654868-1mg	MyBiosource	1mg	EUR 655

IgG2a, Mouse
MBS654868-5x1mg	MyBiosource	5x1mg	EUR 2795

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807332-01mg	MyBiosource	0.1mg	EUR 485

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807332-5x01mg	MyBiosource	5x0.1mg	EUR 1920

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807336-01mg	MyBiosource	0.1mg	EUR 490

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807336-5x01mg	MyBiosource	5x0.1mg	EUR 1945

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807358-01mg	MyBiosource	0.1mg	EUR 440

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807358-5x01mg	MyBiosource	5x0.1mg	EUR 1705

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS806986-01mg	MyBiosource	0.1mg	EUR 490

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS806986-5x01mg	MyBiosource	5x0.1mg	EUR 1940

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807024-01mg	MyBiosource	0.1mg	EUR 490

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807024-5x01mg	MyBiosource	5x0.1mg	EUR 1945

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807052-01mg	MyBiosource	0.1mg	EUR 485

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807052-5x01mg	MyBiosource	5x0.1mg	EUR 1925

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807124-01mg	MyBiosource	0.1mg	EUR 480

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807124-5x01mg	MyBiosource	5x0.1mg	EUR 1910

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807249-01mg	MyBiosource	0.1mg	EUR 485

Mouse Anti-Human PP5 Monoclonal IgG2a
MBS807249-5x01mg	MyBiosource	5x0.1mg	EUR 1930

Anti-inflammatory glucocorticoid action: genomic insights and emerging concepts.

Glucocorticoids (GCs) are widely used immunomodulators. They regulate gene expression by binding and activating the Glucocorticoid Receptor (GR), but underlying transcriptional mechanisms remain enigmatic. This review summarizes recent findings identifyingspecific GR-bound DNA sequences whose configuration may affect transcriptional output.

Additional factors affecting GR’s anti-inflammatory actions, including different chromatin states such as DNAse hypersensitive regions and histone marks will be discussed, together with the relevant transcriptional co-regulators and promoter/enhancer features. Furthermore, the involvement of non-coding RNAs such as lncRNAs, miRNAs and eRNAs adds another level of regulation to the GR’s transcriptional activity. Characterizing and understanding these multiple mechanisms will be crucial for developing more targeted immunomodulatory therapies with reduced adverse effects such as obesity, diabetes and osteoporosis.